The Psychodynamic And Humanistic Perspective - 1640 Words

Personality is a â€Å"pattern of relatively permanent traits and unique characteristics that give both consistently and individuality to a person’s behaviour† (Feist, pg. 4). The two perspectives we will be exploring are the psychodynamic and the humanistic perspective. The psychodynamic theory; influenced by the work of Sigmund Freud; stresses that our unconscious mind plays a major part in an individual’s personality, whereas, the humanistic theory; influenced by the work of Abraham Maslow; focuses on free will and experience in the development of personality. I chose these two theories because they both have contradicting explanations of what they believe personality is and I wanted to explore their ideas and beliefs. When analysing the Psychodynamic perspective we can argue that it emphasises on the individual’s unconscious psychological processes in determining their day to day thoughts, feelings and behaviours. Freud believed the mind was mostly hidden and based his theory on three assumptions; personality is down to human experience, human functioning and the foundation of personality. Human experience explores the idea that our mind takes place on three levels of consciousness; the conscious, the preconscious and the unconscious. The conscious refers to the only level of mental life available to us which we are aware of such as, our memory, feelings and sensations. The preconscious signifies the experiences that are not currently conscious but can become so, forShow MoreRelatedPsychodynamic approach: the basics1202 Words   |  5 Pagesare; Psychodynamic approach and the humanistic approach. I will discuss these 2 psychological theories of development and explain how it accounts for t he psychological development, health and behaviour of the individual. Sigmund Freud (1856-1939) was considered the founding father of the psychodynamic approach. Psychodynamic theory is a view that explains personality in terms of conscious and unconscious forces, such as unconscious desires and beliefs, Sigmund Freud proposed a psychodynamic theoryRead MoreMajor Depressive Disorder ( Mdd )1363 Words   |  6 Pagesas bereavement. The levels of severity are mild, moderate and severe. Different treatments may be used for Major Depressive Disorder. The three most commonly used perspectives are cognitive-behavioral, humanistic and psychodynamic; although the most commonly used is Cognitive-Behavioral Therapy (CBT). Cognitive-behavioral perspective can be used alone or with medication to treat depression. At the origin of Cognitive Behavioral Therapy, it is assumed that an individual’s mood is directly relatedRead MoreDifferent Types Of Theoretical Orientations1612 Words   |  7 Pagestypes of theoretical orientations that a student may choose to identify him or herself with. Although students may choose a specific theoretical orientation they may change their orientation later on in their academic career depending on their perspective of the field. Each orientation is equal, neither orientation is better than the other. Just because a person picks a certain orientation doesn’t mean that their psychological assessment will be any longer or shorter. Its important that a studentRead MorePsychodynamic And Humanistic Theories Of Psychology1634 Words   |  7 PagesPsychodynamic and Humanistic Personality Theories The study of the human mind is an interesting topic to discuss about, we have many theorists that have come up with many different ideas or theories, in how to evaluate the mind of humans, two main ways to study the mind in psychology are psychodynamic approach and humanistic approach. Even though these theories are to evaluate human minds they have different views in how the mind works. In psychodynamic approach, the way the mind is viewed is thatRead MorePerspectives of Psychology1141 Words   |  5 PagesPerspectives of Psychology Psychology can be defined as the systematic study of mental processes, couple with behaviors, and experiences (Kalat, 2011). There are many ways in examining, mental processes and behaviors among people, and therefore psychologist uses different perspectives to understand how human beings, think, act, and behave. Some psychologist uses one perspective to analyze behaviors, and other uses a multidimensional approach. Carter Seifert (2013) identified 7 major perspectivesRead MorePersonalities Theories Paper785 Words   |  4 Pagestheorized several understandings of a human beings character from a humanistic and psychodynamic perspective. Sigmund Freud, an Austrian psychiatrist, developed the psychodynamic theory which is derived from psychoanalysis. This theory is based on several key factors of personality. Freud used this technique in his study of mental disorders while observing his patients. According to Stedman’s Medical Dictionary, psychodynamic is the theory and systematic study of the psychological forces thatRead MorePsychology : Psychology And Psychology1300 Words   |  6 PagesPsychology There are six modern psychological perspectives. These perspectives are behavioral, psychodynamic, humanistic, cognitive, social, cultural, and biological. Each perspective has its own unique way of explaining human behavior. I think that really explains the complex mental processes and behavior, and each prospective study should not be limited to just one. The following is my explanation of the terms and comparisons between the psychodynamic and behavioral aspects relating to the OctoberRead MoreTheories Of Pe rsonality : Psychodynamic, Trait Or Five Factor Model, Humanistic, And Social Cognitive974 Words   |  4 Pagespersonality: psychodynamic, trait or five-factor model, humanistic, and social-cognitive. The psychodynamic theory primarily focuses on the role of the unconscious mind. The social cognitive theory focuses on the effect of the environment on behavior and is based on theories of learning. Whereas, the humanistic theory emphasizes conscious life experiences and choices. The trait or five-factor model focuses on characteristics themselves and not the roots of personality. To begin, the psychodynamic theoryRead MorePersonality, Cognitive, And Humanistic Perspectives Essay1373 Words   |  6 Pagesfive basic dimensions extraversion, agreeableness, conscientiousness, neuroticism and openness to experience. (Soto, J. C, Jackson J. J. 2013). However to get a more in depth understanding of personality the psychodynamic and humanistic perspectives are good to look at. The psychodynamic perspective was developed by the 20th century’s most influential and controversial psychologists Sigmund Freud (1856-1939). Freud was one of the first psychologists to discuss the unconscious mind and its role in behaviourRead MoreFour Major Approaches to Clinical Psychology1803 Words   |  7 PagesThere are many approaches to clinical psychology; the four major approaches are in psychodynamic, cognitive-behavioral, humanistic, and family systems. Using the four major approaches contributes to the effectiveness in treatment by identifying the goals of each approach. The paper will break down the approaches, goals, techniques, and the overall approaches used. Philosophical Origins of Clinical Psychology ApproachesAs Thomas Plante (2005) cleverly suggested, clinical psychology is both a science

Fetal Brain Development and the Preterm Infant - 1554 Words

FETAL BRAIN DEVELOPMENT AND THE PRETERM INFANT 2 NORMAL FETAL BRAIN DEVELOPMENT Embryonic brain development begins a few weeks after conception through the processes known as gastrulation and neurulation (Gilbert, 2000). During gastrulation the embryo changes from a simple group of cells to a multi-layered organism. Three germ layers are formed during this process: the endoderm, mesoderm, and ectoderm (Gilbert, 2000). The endoderm is the most inner layer and forms the lining of internal organs. The mesoderm is the middle layer which forms the skeletal, muscle, and circulatory systems. The ectoderm is the outer most layer which forms the skin, brain and nervous system. During the process of neurulation the ectoderm, the outermost germ layer, goes through a thickening process which in turn forms the neural plate. With changes in cell attachment and shape, the plate beings to rise and fold eventually with both sides meeting in the middle creating a tube (Gilbert, 2000). This tube pulls away from the ectoderm forming what is termed as the neural tube. â€Å"By 27 days, the tube is fully closed and has already begun its transformation into the brain and spinal cord of the embryo† (Zero to three). Failure of the neural tube to close can result in the cerebral cortex not being able to be formed or in spina bifida. Cells called neural progenitor cells, which formed and differentiated in the ectoderm during gastrulation, begin forming the brain, hind brain and the spinalShow MoreRelatedEffects Of Depression During Pregnancy On Children Essay1540 Words   |  7 Pagesactivities decrease and are less responsive to stimulants. Due to stress hormones, the fetuses have low birth weight and are at a higher risk of preterm delivery. Prenatal depression has been noted to be able to predict the likelihood of postpartum depression from hormones such as low dopamine. Depression during pregnancy negatively affects the development of offspring. One of the first studies on prenatal depression showed that fetuses of depressed mothers had less total movement, and had a higherRead MoreThe Effects Multiple Births Have on Outcomes of Cerebral Palsy in Infants987 Words   |  4 PagesMultiple Births Have on Outcomes of Cerebral Palsy in Infants Cerebral palsy is typically characterized as a disorder caused by injuries to the cerebrum, the part of the brain responsible for higher mental functions, sensations, and voluntary muscle actions (7). Symptoms of cerebral palsy vary by severity of the disease, and include seizures, involuntary muscle contractions, difficulty sucking or feeding, irregular breathing, delayed development of motor skills, motor-mental retardation, mentalRead MoreNursing Case Study1450 Words   |  6 Pages40%) newborns exposed in utero to SSRIs and in 1083 of 67,636 (1.60%) non-exposed newborns. Knudsen et al.,(52) conducted a cohort study based on Danish administrative register data and included all newborn diagnosed with congenital heart defect, fetal deaths and in pregnancies terminated due to congenital anomalies. The use of SSRI was assessed. They identified 546 fetuses with congenital heart anomalies (519 livebirths, 12 stillbirths, 2 miscarriages, and 13 termination of pregnancy) and of theseRead MoreThe Efficacy Of Massage Therapy On Preterm Infants2963 Words   |  12 Pages The Efficacy of Massage Therapy on Preterm Infants Taryn L. Metz Winona State University The Efficacy of Massage Therapy on Premature Infants According to the Centers for Disease Control and Prevention (2013) 500,000 infants are affected by preterm births each year. A preterm infant is born prior to 37 weeks’ of their gestational age (Smith, 2012) and can be classified as very premature (less than 32 weeks’ gestation), premature (born between 32 and 34 weeks’ gestation) or late prematureRead MoreNutrition During Pregnancy Is Extremely Important During Fetal Growth And Development1784 Words   |  8 PagesIt is in human nature to want better for your children than you previously had Nutrition during pregnancy is extremely important during fetal growth and development Micronutrients are necessary for normal growth and development of the fetus and deficiencies have been found to be associated with fetal growth retardation and small for gestational age infants (9). Even some animal models have shown that micronutrient deficiencies during pregnancy can potentially increase adiposity to the offspring atRead MoreParental Influence On Children s Cognitive Development1260 Words   |  6 PagesAbstract: The following literature review contains different articles that support how relevant is parental influence on their children’s cognitive development. Since a child is born, parents play such an important role in their children’s cognitive development, that failing at doing the proper steps of assuring a correct development in their children affects their children’s academic success in life. Parents could make their children’s future goals achievable or almost impossible, and trace theRead MoreWhy Pregnant Substance Abuse Shou ld Be Treated As A Major Issue1441 Words   |  6 Pagesnone to extremely harmful. Women who use drugs during their pregnancy commonly give birth to â€Å"crack babies† or â€Å"drug babies†. These babies can have developmental disabilities or other birth defects. The mother may give birth to a premature infant, underweight infant, or even have a stillborn birth. The drug use of a pregnant woman has a direct impact on the baby. While the mother is ingesting methamphetamine, marijuana, cocaine, alcohol, tobacco, or even caffeine, the fetus is also taking it in. ForRead MoreMaternal Stress And Depression And Stress2020 Words   |  9 Pagesthus affecting her relationship with her baby. Recent research evidence has highlighted that there is some overlap between the symptoms of maternal depression and stress (Cheng Pickler, 2014), and that these play a role in affecting the normal development of the fetus. However, other research has indicated that stress and depression do not harm the fetus, and in fact can be developmentally beneficial (DiPetro, 2004). In this essay, a number of symptoms of maternal stress and depression shall be addressedRead MorePrevalence Of Depression Among Pregnant Women1465 Words   |  6 Pagesmost popular antidepressants taken during pregnancy. Side effects that could take place from these antidepressants are persistent pulmonary hypertension of the newborn, ADHD, increased chances of spontaneous abortion, and smaller birth size in the infant.3,4 Introduction: When a woman is pregnant it is extremely important that she is physically and emotionally healthy. Depression is a common psychiatric disorder among many people. Depression tends to have a social stigma attached to it, so many peopleRead MoreEthical Issues Involved in Research on Children2115 Words   |  8 Pagesï » ¿Questions Advantages and disadvantages of experiments when researching child development The experimental method in researching child development has been greatly used by researchers. It has several advantages and disadvantages. One advantage is that it helps to prove a hypothesis through the collection of data on independent or dependent variables in a closed or open environment. Experiments help to create the ideal environment for the researcher to study the phenomenon. However, it suffers the

Cbse Chemistry Notes for 11 and 12 Free Essays

string(34) " near to the most probable speed\." Supplementary Textual Material in Chemistry for Class XI Class XII 1 Acknowledgements CBSE ADVISORS Shri Vineet Joshi, I. A. S. We will write a custom essay sample on Cbse Chemistry Notes for 11 and 12 or any similar topic only for you Order Now , Chairman, CBSE Shri Shashi Bhushan, Director (Acad. ), CBSE CONVENOR EDITOR Prof. A. K. Bakhshi Department of Chemistry, University of Delhi. DEVELOPMENT TEAM Prof. A. K. Bakhshi Department of Chemistry, University of Delhi. Dr. Anju Srivastava Hindu College, University of Delhi. Dr. Vimal Rarh S. G. T. B. Khalsa College, University of Delhi. Dr. Geetika Bhalla Hindu College, University of Delhi. Ms. Anupama Sharma Modern School, Vasant Vihar, New Delhi. MEMBER COORDINATOR Dr. Srijata Das, Education Officer, CBSE 2 TABLE OF CONTENTS Class XI Unit 5 : States of Matter 5. 7. 1 Kinetic Energy and Molecular Speeds 5. 7. 2 Maxwell-Boltzmann distribution of molecular speeds Unit 6 : Thermodynamics 6. 6. 1. Second Law of Thermodynamics 6. 8. Third Law of Thermodynamics Unit 7 : Equilibrium 7. 12. 1 pH of Buffer Solutions Class XII Unit 16 : Chemistry in Everyday Life 16. 4. 2. 1 Antioxidants 3 Unit 5: States of Matter 5. 7. 1 KINETIC ENERGY AND MOLECULAR SPEEDS As you have studied in the previous section the molecules of a gas are always in motion and are colliding with each other and with the walls of the container. Due to these collisions the speeds and the kinetic energies of the individual molecules keep on changing. However at a given temperature, the average kinetic energy of the gas molecules remains constant. If at a given temperature, n1 molecules have speed v1, n2 molecules have speed v2, n3 molecules have speed v3, and so on. Then, the total kinetic energy (EK) of the gas at this temperature is given by where m is the mass of the molecule. The corresponding average kinetic energy ( If the following term Then the average kinetic energy is given by where c is given by 4 ) of the gas will be This ‘c’ is known as root-mean-square speed. As the name implies, to calculate c, first take the squares of the individual speeds, then their mean and finally the square root of the mean. It can be shown that c is related to temperature by The average kinetic energy depends only on absolute temperature and is related to absolute temperature by the expression where k = Boltzmann constant = 1. 38 x 10-23 J K-1 In the case of gases, one also talks of two other speeds, namely, average speed and most-probable speed. The average speed ( ) at a given temperature is the arithmetic mean of the speeds of different molecules of the gas. . e, where n1 molecules have speed v1, n2 molecules have speed v2, n3 molecules have speed v3, and so on. The relationship between average speed and temperature T is given by The most probable speed ( ) of a gas at a given temperature is the speed possessed by the maximum number of molecules at that temperature. Unlike average speed and root mean sq uare speed, the most probable speed cannot be expressed in terms of the individual molecular speeds. The most probable speed ( ) is related to absolute temperature (T) by the expression 5 Relationship between different types of molecular speeds The three types of molecular speeds, namely, most probable speed ( ), average speed ( ) and root mean square speed (c) of a gas at a given temperature are related to each other as follows: For a particular gas, at a particular temperature, It follows from the above relationships that Example: Calculate the root mean square, average and most probable speeds of oxygen molecules at 27 oC. Solution: Given data: Molar mass of oxygen, M = 32 g mol-1 = 0. 032 kg mol-1 Temperature, t = 27 oC T = (27 + 273) K = 300 K 6 Expressions to be used: Root mean square speed, Average speed, Most probable speed, Actual calculations Root mean square speed, Average speed, Most probable speed, 5. 7. 2 MAXWELL-BOLTZMANN DISTRIBUTION OF MOLECULAR SPEEDS The speeds of the individual molecules of a gas do not remain constant. They keep on changing due to inter molecular collisions and due to collisions with the walls of the container. However, at a given temperature, the distribution of molecular speeds remains constant. This distribution of molecular speeds is given by Maxwell-Boltzmann distribution law. 7 For a given gas, at a given temperature, the distribution curve of molecular speeds is shown in Figure 5. 7. 1 Figure 5. 7. 1. Maxwell Boltzmann distribution curve You can see from the distribution curve that it is the plot of molecular speed vs the fraction of molecules. The important features of this distribution curve are: (i) The fraction of molecules having too low or too high speeds is very small. (ii) There is a certain speed for which the fraction of molecules is maximum. This speed is known as most probable speed. (iii) The most probable speed of a gas, is the speed possessed by the maximum number of molecules of the gas at a given temperature and it corresponds to the peak of the curve. Since the most probable speed ( xpression ) is related to absolute temperature T by the It means that at the same temperature, lighter gases shall move faster than heavier gases as is evident from the distribution curves of chlorine and nitrogen gases in Figure 5. 7. 2. 8 Figure 5. 7. 2. Maxwell Boltzmann distribution curves for chlorine and nitrogen gases at 300K Effect of temperature In Figure 5. 7. 3. are given t he Maxwell Boltzmann distribution curves of a gas at three different temperatures T1, T2 and T3 such that T1gt;T2gt;T3. Figure 5. 7. 3. Maxwell Boltzmann distribution curves for a gas at three different temperatures 9 It can be seen from these distribution curves that as the temperature increases 1. The entire curve shifts towards right. 2. The most probable speed increases. 3. The fraction of molecules having most probable speed decreases. 4. The curve becomes broader in the middle range indicating that more molecules have speeds near to the most probable speed. You read "Cbse Chemistry Notes for 11 and 12" in category "Papers" 5. The fraction of molecules having higher speeds increases. 6. The fraction of molecules having lower speed decreases. It may be noted that the total area under each of the curves remains the same as the sum of fractions of molecules remains unaltered on changing the temperature. 0 EXERCISE 1. Calculate (i) root mean square speed (ii) average speed and (iii) most probable speed of CO2 molecules at 700 K . 2. A sample of a gas contains 15 molecules with a speed of 3 m s-1, 25 molecules with a speed of 5 m s-1 and 30 molecules with a speed of 8 m s-1. Calculate root mean sq uare speed of these molecules. 3. Calculate the temperature at which the average speed of oxygen equals that of hydrogen at 20 K. 4. Calculate the temperatures at which the root mean square speed, average speed and the most probable speed of oxygen gas are all equal to 1500 m s-1. Answers 1. i. 629. 92, m s-1 ii. 80. 50 m s-1 iii. 514. 33 m s-1 2. 6. 187 m s-1 3. 320 K 4. T for root mean square speed= 2886 K, T for the average speed = 3399 K, T for most probable speed = 4330 K 11 12 Unit 6 : Thermodynamics 6. 6. 1 SECOND LAW OF THERMODYNAMICS You have already studied in the previous sections that the first law of thermodynamics deals only with the law of conservation of energy and it gives no information about the criteria for feasibility of a given physical or chemical process. This law is always obeyed whether a given process occurs on its own or is made to occur with the help of an external agency. In any case the first law is valid in both the forward and reverse direction of the process. You have also learnt about the concept of entropy which is a measure of the randomness or the disorder in a system. This concept helps in explaining the spontaneity of the irreversible processes. For an irreversible process, the entropy of the system and surroundings taken together i. e. of the universe increases, while for a process at equilibrium it remains constant. This conclusion is of great importance as it helps us to predict whether a given process can take place spontaneously or not. Since all processes in nature occur spontaneously i. e. irreversibly, it follows that the entropy of the universe is increasing continuously. This important statement i. e. â€Å"in any spontaneous process, the entropy of the universe (system and surroundings) always increases† is also known as the second law of thermodynamics. ?SUniverse = ? Ssystem + ? Ssurroundings Specifically it means that If ? SUniverse gt; 0, the reaction is spontaneous If ? SUniverse lt; 0, the reaction is non-spontaneous If ? SUniverse = 0, the reaction is at equilibrium Since chemists are generally more interested in the system (reaction mixture) than the surroundings, it is therefore more convenient to restate the second law in terms of the thermodynamic properties of the system, without regard to the surroundings. As already described in the previous section, this is possible through the Gibbs free energy G which for a system is defined as G = H – TS. In terms of this thermodynamic property, the second law of thermodynamics can be restated as in any spontaneous process at 13 constant temperature and pressure, the free energy of the system (? Gsystem) always decreases. According to this definition If ? Gsystem lt; 0, the reaction is spontaneous If ? Gsystem gt; 0, the reaction is non-spontaneous If ?Gsystem = 0, the reaction is at equilibrium 6. 8. THIRD LAW OF THERMODYNAMICS The third law of thermodynamics is concerned with determination of entropy. It states that a substance which is perfectly crystalline at absolute zero of temperature has an entropy of zero. In a perfect crystal at absolute zero of temperature, each constituent of the crystal (atom, molecule or ion) is at the proper crystal lattice site and it therefore has the lowest energy. This means that this particular state is of perfect order, i. e, has zero disorder and hence zero entropy. Using zero value of entropy at absolute zero for a perfectly crystalline substance as the reference point (initial state), one can calculate absolute value of entropy of the substance in any state (solid, liquid or gas) at any temperature by calculating ? S for the process/es in going from the initial state to the state of the substance for which entropy is to be calculated. However there are certain substances which possess certain entropy even at absolute zero. This entropy is known as residual entropy. The origin of residual entropy can be explained on the basis of the disorder which remains at absolute zero in certain crystals composed of AB types of molecules where A and B are similar atoms (as in CO). In such substances, there is a very little energy difference between â€Å"†¦AB AB AB†¦Ã¢â‚¬  and â€Å".. †¦AB BA BA AB†¦.. † and other arrangements so that the molecules adopt the orientations AB and BA at random in the solid. This gives rise to some disorder, also known as frozen disorder, and consequently residual entropy. For example in case of CO, the measured residual entropy is 5 J K-1 mol-1 which is close to the value expected for a random structure Figure 1 (B) of the form â€Å"†¦Ã¢â‚¬ ¦CO CO OC CO CO OC OC†¦Ã¢â‚¬ . 14 Figure 1. Alternative molecular arrangements for CO (A) Perfect crystal (B) Actual crystal EXERCISE 1. State Second Law of Thermodynamics. 2. Write the conditions in terms of ? H and ? S when a reaction would be always spontaneous. 3. When ? H gt; 0 and ? S lt; 0, a reaction is never spontaneous. Explain. 4. Comment on the spontaneity of a reaction at constant temperature and pressure in the following cases i) ? H lt; 0 and ? S gt; 0 (ii) ? H gt; 0 and ? S lt; 0 (iii) ? H lt; 0 and ? S lt; 0 (iv) ? H gt; 0 and ? S gt; 0 5. State third law of thermodynamics. 6. Explain the term residual entropy. 15 Unit 7: Equilibrium 7. 12. 1 pH OF BUFFER SOLUTIONS : HENDERSON – HASSELBALCH EQUATION As you have already learnt in the previous section a buffer solution is a soluti on which resists change in its pH on the addition of small amount of acid or a base. Most of the important buffer solutions generally consist of mixtures of weak acids and their salts or weak bases and their salts. These buffer solutions are known as acidic buffers and basic buffers respectively. If the pH of the buffer solution is less than 7, it is called an acidic buffer and if the pH of the buffer solution is greater than 7 it is called a basic buffer. Examples of some acidic and basic buffers are as given below Acidic buffer Basic buffer 1) Acetic acid and sodium acetate 1) Ammonium hydroxide and ammonium chloride 2) Formic acid and sodium formate 2) Ammonium hydroxide and ammonium nitrate pH of an acidic buffer A very common example of an acidic buffer is a mixture of acetic acid and sodium acetate. Acetic acid, being a weak acid, is very slightly dissociated, while sodium acetate being a salt is completely dissociated. The mixture thus contains acetic acid molecules as well acetate ions and sodium ions. At equilibrium: CH3COOH(aq) H+ (aq) + CH3COO-(aq) Taking the negative logarithm on both the sides, we get 16 †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦(7. 39) In general, †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦(7. 40) It may be noted that the concentration of the acetate ions is taken to be almost equal to the concentration of the salt because the acetate ions coming from fully dissociated salt (here sodium acetate) suppress the ionization of the weak acid (acetic acid). This equation (7. 0) is called Henderson- Hasselbalch equation. According to this equation, the pH of an acidic buffer consisting of a mixture of a weak acid and its salt depends on the pKa of the acid, and the concentrations of the salt and acid in the mixture. If concentration of the sa lt is equal to that of the acid, then Buffer action of Acidic buffer The buffer action of an acidic buffer consisting of a mixture of acetic acid and sodium acetate can be explained in the following way. If we add small amount of HCl to the buffer solution it will ionise to give H+ ions. These combine with CH3COO- ions to form weakly ionized acetic acid. CH3COO-(aq) + H+(aq) ? CH3COOH(aq) + H2O(l) Since H+ ions get neutralised by CH3COO- ions, there will be no change in pH. On the other hand, if we add a few drops of NaOH to the buffer solution, it provides OH- ions which are neutralized by the acetic acid present in the mixture. 17 OH-(aq) + CH3COOH(aq) ? CH3COO-(aq) + H2O(l) Therefore the pH of the solution remains unchanged. pH of a Basic Buffer A very common example of a basic buffer is a mixture of ammonium hydroxide and ammonium chloride. Ammonium hydroxide being a weak base is very slightly dissociated, while ammonium chloride being a salt is completely dissociated. The mixture thus contains ammonium hydroxide molecules as well as ammonium ions and chloride ions. At equilibrium, NH4OH(aq) NH4+(aq) + OH-(aq) Taking the negative logarithm on both the sides, we get †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦(7. 41) In general, †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦(7. 42) 18 It may be noted that the concentration of the ammonium ions is taken to be almost equal to the concentration of the salt because ammonium ions coming from the fully dissociated salt (here ammonium chloride) suppress the ionization of the weak base ammonium hydroxide. This equation (7. 42) is called Henderson- Hasselblach equation. Further, pH can be calculated easily from pOH using Hence, It may be noted that pKa + pKb = 14 Buffer action of basic buffer The buffer action of a basic buffer consisting of a mixture of ammonium hydroxide and ammonium chloride can be explained in the following way. If a few drops of HCl are added to the buffer solution, it will ionise to give H+ ion which will combine with OH- ions to form H2O. H+(aq) + OH- (aq) ? H2O(l) Therefore, the addition of HCl will not change the pH. On the other hand, when a few drops of NaOH solution are added to the buffer solution, it would give OH- ions. These OH- ions combine with NH4+ ions present in the solution to form NH4OH, which is only slightly ionised. OH-(aq) + NH4+ (aq) ? NH4OH(aq) Hence, the addition of a base also will not change the pH. 19 EXERCISE 1. A certain buffer is made by mixing sodium formate and formic acid in water. With the help of equations explain how this buffer neutralizes addition of a small amount of an acid or a base. 2. A basic buffer is made by mixing ammonium hydroxide and ammonium nitrate in water. Explain how this buffer resists change in its pH on addition of a small amount of an acid or a base. 3. What would be the pH of a solution obtained by mixing 10 g of acetic acid and 15 g of sodium acetate and making the volume equal to 1 L. Dissociation constant of acetic acid at 25oC is 1. 75 x 10-5. 4. A buffer solution contains 0. 40 mol of ammonium hydroxide and 0. 50 mol of ammonium chloride to make a buffer solution of 1 L. Calculate the pH of the resulting buffer solution. Dissociation constant of ammonium hydroxide at 25oC is 1. 81 x 10-5. Answers 3. pH = 4. 80 4. 9. 161 20 Class XII Unit 16: Chemistry in Everyday Life 16. 4. 2. 1. ANTIOXIDANTS Antioxidants are one of the important and necessary food additives. These compounds retard the action of oxygen on food thus reducing its speed of decomposition by oxidation. Hence they help in the preservation of food. These act as sacrificial materials, i. e. these are more reactive towards oxygen than are the materials they are protecting. They also reduce the rate of involvement of free radicals in the aging process. Examples: The two most familiar antioxidants used are butylated hydroxy toluene (BHT) and butylated hydroxy anisole (BHA) (Figure 1). These phenolic compounds are added to preserve fats in packaged food. Oxygen reacts preferentially with BHA or BHT rather than oxidizing fats or oils, thereby protecting them from spoilage. The addition of BHA to butter increases its storage life from months to years. Sometimes, BHT and BHA are added in combination with citric or ascorbic acids to produce a more active synergetic effect. Figure 1: Butylated hydroxy toluene (BHT) and butylated hydroxy anisole (BHA) Sulphur dioxide and sulphites ( such as sodium sulphite, sodium bisulphite and sodium metabisulphite) are useful antioxidants for wine and beers, sugars syrups and cut, peeled or dried fruits and vegetables. They prevent or reduce their discoloration. 21 EXERCISE 1. Name one antioxidant commonly used to increase the storage life of butter. 2. Name one antioxidant used in wine and beers. 22a How to cite Cbse Chemistry Notes for 11 and 12, Papers

Dibetes Melitus an Increasing Health Problem all over the World

Question: Discuss about the One Social Determinant that may Impact upon Population-Level Rates of Diabetes and related Complications. Answer: Dibetes Melitus (DM) is a increasing health problem throughout the entire world and near about 177 million people are suffering with the same disease. It is expected to rise up by 300 million in 2025 in Asia and Africa by 2025.Apart from that Uganda is suffering from upsurge of diabetes. Thus in order to discuss general study of population we took a random sample from Kampala capital city and its adjacent town Mukono the existence is estimated to rise by 8.1%.Basically adherence to proper medication of Anti diabetic drugs are prescribed often by the doctors. This medication is often followed by proper diet and also bringing changes in life style can provide can improve the condition of the suffering patient (Perwitasari Urbayatun ,2016) But at the same time due to non-adherence medication with diabetic patients can affect the treatment of the patients and can ultimately lead to death in that case. This will impact the health of the patient directly or indirectly. Apart from that the magnitude and scope of non-adherence effect is too high thus it is important to follow the adherence to the existing treatments rather than developing new medical conditions. A study in United States proves that people who did not followed proper medical treatment suffered most than the ones who followed adherence. Generally there is emphasis on the patients to understand the proper medication in spite of that patients rarely adhere to the drugs in case of chronic diseases and thus they are not able to achieve their individual health goals. The associated factors with Non Adherence are usually centered by the patients itself. They are usually therapy related or health care related. The factors which are centered by the patients may be therapy related (Hindawi, 2011) The factors which are patient related can be often demographic demographic (gender, age, education level and marital status) whereas psychological factors include motivation and beliefs of patients towards the therapy, patient-prescriber relationship, health issues understanding, negative attitude and knowledge of the patients. The factors related to therapy generally conclude to duration of treatment, medication route, treatment complexity, medication type and side effects of medicines. Main factors related to healthcare generally include accessibility and availability of healthcare and the interactions with patients with healthcare. (NCBI, 2009) There are many individual adults suffering from dibetis thus they go for antihyperglycemic medications or insulin along with proper exercise and diet so that they are able to maintain their body blood sugar level. It is very essential to adhere with the oral based antihyperglymic medications as it helps in long time glycemic control (1-3) in the body. At the same time the entire level of non adherenece is prescribed to regimens among other list of patients usually ranges are from 9% to 80% along with high rate in symptom free patients .A recent study states that individuals suffering from the disease are usually taking medications based on glycemic control and also from typical comorbidities of diabetes such as dyslipidemia and hypertension. Apart from that the drug regimen of patients suffering from this disease is now becoming extremely complex thus adherence can be a big challenge in this case. Nonadherence is usually named as Medication possession ratio (MPR) 80%..Multivariate lo gistic regression analysis are often performed where hospitalization is regressed to non adherence to oral antihyperglycemic drug regimen .Oral antihyperglycemic therapies are very useful to decrease glucose levels among the other patients in case of type 2 dibetis. Hence it lowers the risk of developing microvacular and macrovascular problems. But at the same time we must note that the nonadherence oral medication and hospitalization treatments is not developed much in case of patients suffering from dibetis. The past studies have proved various potential risk factors due to non adherence towards medicines across various medical conditions. Often mentioned factors of risk include ethnicity, sex ,income, education, age, co-morbidity through their relationship with prescribed medical treatment or adherence is generally inconsistent because of variation in sample population and study designs. The side effects related to medication also come under non-adherence. A sample related to non-adherence was done in Uganda urban hospital and it has indicated long term interval to a facility visit. It has demonstrated that patients do not understand the regimen of drug and inability to afford medicinal cost of drugs associated with non-adherence. The diet plan explanation and proper method to follow it is usually related to adherence (Cramer, 2004) If we talk about Uganda sample study taking into consideration social population then we will find out that there is literature scarcity on diabetic treatment adherence in rural areas and the population is very poor with less health care facilities. Apart from that the amount of patients suffering to diabetes over there is increasing day by day. Hence it is very much essential to rectify factors associated to medical adherence. Therefore various studies were conducted in developed countries where there is vast gap in knowledge about the occurrence and factors which are related with the adherence to diabetic treatment in rural areas. Further there are factors related to adherence to anti diabetic medication in the eastern parts of Uganda. Thus it will guide the interventions for improving adherence to drug and optimal glycemic control in patients suffering with diabetics in the rural areas (Delamater, 2006) The following conditions in the rural areas demonstrate that due to lack of availability of healthcare conditions there is vast increase in diabetes thus it's important to improve the same so that the patients suffering from this disease can recover after proper adherence .These conditions are not only prevailing in Uganda but in almost all the rural areas of the world where the medical facilities are not fully provided. References: NCBI, 2009., Nonadherence and factors affecting adherence of diabetic patients to anti-diabetic medication in Assela General Hospital, Oromia Region, Ethiopia, [Online] Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832902/ [Assessed 2 April 2017]Hindawi, 2011 .,Nonadherence and Contributing Factors among Ambulatory Patients with Antidiabetic Medications in Adama Referral Hospital . [Online] Available at: https://www.hindawi.com/journals/jdr/2014/617041/ [Assessed 2April2017] Cramer. J, 2004., A Systematic Review of Adherence With Medications for Diabetes .[Online] Available at: https://care.diabetesjournals.org/content/27/5/1218 [Assessed 2April 2017]Delamater.A , 2006 ., Improving Patient Adherence .[Online] Available at : https://clinical.diabetesjournals.org/content/24/2/71 [Assessed 2 April 2017] Perwitasari .D Urbayatun .S ,2016.,Treatment Adherence and Quality of Life in Diabetes Mellitus Patients in Indonesia.[Online ]Available at : https://journals.sagepub.com/doi/abs/10.1177/2158244016643748 [Assessed 2 April 2017]

Reasons for Colonial Immigration free essay sample

Although politics, religion, and the economy were all huge factors leading up to this historic occurrence, one influence rose above them all: economics. Money seemed to truly â€Å"make the world go ‘round†. The issues that spurred the least amount of inspiration for the exodus to the Americas were the political issues currently causing chaos in Europe. Many of the governments of Europe were dominated solely by the nobility and landed elite, so the common person barely had any say in the government. This would cause many middle-class people, and particularly the lower-class peasantry, to want to travel to the Americas. Class differences were simply too prominent and affected their lives in the most negative way possible. The middle and lower class would be able to start a new life for themselves, and because they would be some of the first people to get to the New World, they would have a greater chance of finding themselves in the seat of power. We will write a custom essay sample on Reasons for Colonial Immigration or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Also, many individuals felt too controlled by a smothering, oppressive government. As a result, many hoped to seek political freedom in the new lands. Because a government would not have already been established and they would no longer be under direct control of Henry VIII and the church, people thought that they would have more say in political decisions and would have the freedom and â€Å"new beginning† they so deeply desired. Finally, some Europeans sought to escape the political unrest and violent turmoil in their own country. For example, part of England’s new interest in America contributed to its growing rivalry with Spain, which was mainly caused by the Protestant Reformation. European countries were battling for religious nd therefore political power, causing great distress to their citizens as well. By moving to a mostly â€Å"uninhabited† area, naturally the potential immigrants were expecting the peace and political freedom they so desperately longed for. The second most important reason for migrating to the New World was the common desire for religious autonomy and sovereignty. When Henry VIII br oke with the church in 1527, declared himself the head of England’s church, and arranged his own divorce, a pandemonium ensued. Select Englishmen supported the new church, but Puritans and pilgrims wanted to cleanse the Anglican Church of any Catholic elements. They were extremely unhappy that monarchs and bishops controlled the church and that congregations were not allowed to elect their own ministers. Also, when James I became king in 1603 and refused to tolerate these reform ideas, Puritans became even more desperate for religious freedom. Starting their own colonies on the North American continent seemed like the perfect answer to all of their problems. Religious intolerance in the homelands of religious brethren caused them to voyage to America in order to practice religion that they believed to be correct. Religious reasons not only drove the English away from their homelands. By the 1560s, most of the Dutch had also formed their own religious beliefs- Protestantism. When the Spanish government tried to suppress their faith, they rebelled in nearly the same way as the English did. Like almost anybody, they wanted to be allowed to express their religious beliefs and practice things how they chose to. No one wants to be forced to change their beliefs about things as personal, and usually extremely prominent in society, as religion. Lastly and most importantly, Europeans were inspired to settle in the Americas because of economic difficulties at home. Vast numbers of the earliest settlers traveled to the New World in a quest for land. Much of the land in Europe was either controlled by the nobles or by the Church, which left little opportunity to anyone else who didn’t fall under those two categories. It was extremely difficult for an average farmer or rancher to become successful and it would cost a fortune for just a small piece of land. In America, on the other hand, you could get acres upon acres of land dirt cheap. Literally. Another key economic reason for starting a new chapter in their lives was to start out on a fresh slate. A surprisingly large amount of immigrants were either peasants/indentured servants, or had a great debt to pay off back at home. By voyaging to the colonies, they would be able to get a new start. Colonizers would be free of debt and, because the New England colonies were desperate for new settlers and workers, it was exceptionally easy to get a job unlike back at home. Not only would new colonists benefit from new sources of money and erased debt, but they would also be surrounded by new agriculture, bountiful amounts of new staple foods such as corn, and cash crops such as tobacco. Those that were struggling with famines in their home countries would have brand new resources for food, and food is enough to motivate nearly anybody. Not to mention, tobacco was a plant and drug that had never been discovered before, and was a highly profitable commodity. It was in extremely high demand from not only the colonies, but from other countries as well, and people were willing to pay large sums of money for the plant. Despite what many people believe, money truly can buy happiness along with nearly everything else in the world, of course. The 17th century was a hectic time full of new beginnings, particularly in regards to the mass amount of treks to the New World, which would later become known as the United States of America. There were several motives for the big move than many chose to make, the three biggest factors being political, religious, or economic. Politically, distressed citizens were simply seeking a political voice in their own country, and freedom from an oppressive government. Another huge reason for migration involved the religious battles and tensions caused by the Protestant Reformation. People were simply standing up for what they believed in. Most importantly, people were searching for a new beginning and ways to financially stabilize and profit from this opportunity, something they could not do in their homelands. Although the new colonial people may not have pinpointed one specific reason for making their decision, all three factors played a huge role in history, and still do today. Whether people realize it or not, these three things- politics, religion, and economics- influence nearly every decision they make, and will continue to do so until the day pigs fly.

Diet And Primate Evolution Essays - Diets, Primate, Dietary Fiber

Diet And Primate Evolution Essays - Diets, Primate, Dietary Fiber Diet And Primate Evolution Diet and Primate Evolution Variation in the choices of food on a daily, seasonal, and yearly basis is one of the greatest differences between primate species. Primate diets have generally been divided into three main food categories-fruit, leaves and fauna (including insects, spiders, and bird's eggs for the most part). The different diets also are referred to as Frugivores, Folivores, and Insectivores (fruits, leaves and insects respectively). These gross dietary categories are correlated with aspects of primate activity patterns such as home range and group size. There are different problems that have to be overcome in order to obtain a balanced diet on a day-to-day basis. New leaves and mature leaves, for example, may have different nutritional bases or availabilities. Some fruits appear in large clumps while others are spread thinly over a larger area. Aside from diet, primates have tended to either adapt through specialized dentition and digestive systems or rely on a variety of different foods. Those tha t chose this second route have tended to have larger brain sizes relative to their overall body size. This may be due to the need to know where different types of food can be found at different times throughout the year. Have you ever looked at a picture of a gorilla or money that has what appears to be a beer belly look? Those primates that specialize on eating large amounts of vegetation have difficulty digesting their meals. Different solutions have been found including double stomachs or multichewes, but the problem usually requires an individual to sit back and let the digestive system work-and on the die expel gas. It hasn't been until recently that it was realized that primates, who evolved in the canopy, actually had a quite difficult time finding adequate nutrition. Due to natural selection, which strongly favors those traits enhancing foraging efficiency, and this difficulty finding sustenance, the characteristics regarded as belonging to primates were evolved. Most primates species either maximize the efficiency of their digestive track or maximize the quality and the volume of food processed in a day. Also. Those species, which increase the volume of food, consumed also tended to have larger brains because of a need to remember, not only what, but also where good food sources are and when they are in season. Knowing the trends of evolution, the next thing to do is to look at how it relates to humans. It can be seen that out closest living relative, the chimpanzee makes up 94% of his diet with plants. Most of this is fruit with high sugar and fiber content, meaning that chimps take in hundreds of grams of fiber per day; contrary to the 10 grams or less the advantage American consumes. This suggests that our diet should be higher in vitamin C, pectin, and fiber like our relatives in the wild. Ironically, the same natural selection, which favors the most energy-dense and low fiber diets, may now be causing us to suffer from too little fiber. Plants have been a major food eaten by primates. The primates were almost exclusively herbivorous. A strong focus on plant foods is characteristic of all primates and there is strong consensus that the primates were very strongly herbivorous (Milton 1987, 1993). Many plants are lacking vital nutrients, such as vitamins and the protein building blocks known as amino acids, that the monkeys and other animals require. Some plants lack enough carbohydrates to make them worthwhile as energy producers. Yet in all of these cases the primates would still search for specific plants that exhibited one or more of these traits, rather than just rely on the plant life that was within easy reach. The fact that the primates would make an active search from a variety of plants. One particular type of plant may have lacked was often complemented by the positive aspects of another plant. For example, fruits are low in fiber and protein and yet they are rich in valuable carbohydrates. If the primates had relied solely on eating fruit then they would have lacked sufficient protein and vital amino acids. To make up for that particular type of shortage, the monkeys eat certain leaves that are high in protein and

Customer-perceived value Essay Example | Topics and Well Written Essays - 1000 words

Customer-perceived value - Essay Example Customer-perceived value Thus marketers should really work hard so as not only to attract customers, but also retain them by providing the maximum customer perceived value. For instance, Nike which is a well-known brand, endorsed Michael Jordan who is a professional NBA player and came up with a unique line of shoes known as Air Jordan(s).Thus Nike seems to know all too well the importance of developing customer-perceived value that is strong. Eventually all the publicity about the unique line of Air Jordans together with limited edition of Jordans, are all consumer-perceived. Thus such a product is perceived to be having more benefits than the one offered by its competitors making consumers more willing to pay the hiked price so as to get it (Gale & Wood, 1994). Total customer satisfaction is the ability of a product or a service to satisfy the needs of a customer. It is clear that when a business taxes expands or grows more market share than its competitors, the company should focus on the needs of satisfying the customer. Moreover, ensuring that the customers’ needs are met should be a fundamental goal of any business. Customer satisfaction is thus a term constantly used in marketing and is a measure of how services and products that a company supplies meets or surpasses customer expectations.. It is mostly taken as major performance indicator in business and mostly is an aspect of a Balanced Scorecard. Customer satisfaction is taken as a main differentiator in competitive marketplace where companies are in competition for customers and has progressively become a core aspect of business strategy. It is therefore very important for enterprises to efficiently deal with customer satisfaction.

The Relationship between history, theory, and doctrine in the Essay

The Relationship between history, theory, and doctrine in the evolution of military tactics - Essay Example Military Tactic and Strategy Military tactics are the means and art of which an organization of army employs techniques and weaponry to defeat the enemy during battle (Clausewitz, 1832). It is the lowest level of military planning, followed by operational, and encompassed by the highest level which is military strategy. Military strategy has evolved to mean more than war time but now encompass even peace time and the strategies involved to prevent war itself (Lider, 1981). Previously, Clausewitz (1832) defined military strategy as â€Å"the deployment of the battles as the means toward the attainment of the object of war,† (12). Hart (1980) also re-joined with his description as â€Å"the art of distributing and applying military means to fulfil the ends of policy,† (page) both of which imply armed violence. However, it is also notable that strategy meant more that the use of armed violence but covered policy, political, economic, ideological and techno-scientific means of nations in pursuit of victory (Lider, 1981). Earle (1944) included in military strategy even activities of peacetime to encompass non-military factors of economic, psychological, moral, political, and technological aspects to become an art of controlling all the resources of a nations and its allies to secure vital interests against enemies, perceived or otherwise. It integrates all military efforts and policies as a â€Å"grand strategy† for peace and war time. War is the object of which should be prevented or prepared for in peacetime. Osgood (1962) also defined military strategy as â€Å"nothing less than the overall plan for utilizing the capacity for armed coercion – in conjunction with the economic, diplomatic, and psychological instruments of power – to support foreign policy most effectively by over, covert and tacit means,† (5). Third definition of military strategy included both the means and the ends so that it uses the entire state power o r its aggregate potentials to attain the whole or majority of its political goals (Lider, 1981). Holloway (1979) added in the grand strategy all elements of a society’s power to support its security objectives with the main one being the prevention of â€Å"the loss of our way of life† (19). Principles of Military Tactics There are a variety of military tactics employed in battlefield. One of them is the United States’ Army’s version which trains soldiers of the following: Simplicity in a tactical plan maintains simple concept and execution where failure points are avoided. Direct tactics can make other people understand fully their actions and the part of others. This will aid them in contributing to the success of a maneuver. Surprise will keep the enemy wondering and can be employed using subtle appearance in urban self-defense, stealth and deception in battlefield, or any daring action which is least expected by the enemy camp. Speed is doing as fast as possible whatever is needed and be ready for the next long before the enemy has time to react on the first. Security considers safety at all times with its rear and flanks to keep the enemy from doing what the combatant wants to do to them. Violence of action will destroy the will of the enemy to fight (Curahee, 2008) The principle of military tactics also cover the main objective, which is a particular aim such as disengagement from an advancing enemy or maintaining movement through protection of advancing troops. Principles also employ various practical tactics that include

Designing a course in technology-Enhanced learning for Adult learners Essay

Designing a course in technology-Enhanced learning for Adult learners - Essay Example This paper aims to present a discussion that revolves around principles of learning design. The focus is to design a unit assessment plan that will educate 65 year old adults on prevention, treatment, and management of foot related complications. Some of the skills that the unit assessment aims to establish among the older population include synthesis of instruction, exploration skills, designing skills, collaboration, and reflection skills. Technological transformations have prompted the majority of educators to adopt newer and advanced forms of newer technology in teaching. Teachers in institutions of higher learning have opted for the use of e-mails, PowerPoint presentations, education applications, and design Web sites to pass knowledge and information to learners (Caulfield, 2011). The mode of connecting teaching to learning has formed the center of current debate, with critics questioning the validity of the relationship. This is because they have argued that such learning techniques are vulnerable to losing their validity with changes in technology. On the other hand, proponents have highly held the phenomenon, citing their value in expanding the learning and teaching experience. Rogers (2003) maintains that the application of skills in learning and teaching is crucial, as it determines the effectiveness of the teaching and learning experiences. When a new technology emerges, there are various levels that educators should undergo in their endeavors to fully adopt any technological model of teaching (Rogers, 2003). However, recent research has revealed that some learning sessions have not fully benefited from the advantages of employing technological based teaching and learning experiences. This is because of the different degrees of adaptation by teachers. Analysts have argued that educators should follow the right procedure in their quest to make some technology based models of teaching part of their professional initiative. Some of the

Ethics in social research

Ethics in social research Ethics in research has been around since World War II and is still to this day a growing concern among researchers. The main aim of the researcher is to ensure that their studies are directed toward worthwhile goals and that the welfare of their subjects and their research colleagues is protected. Alan Kimmel, 1988 There are several reasons why it is important for an investigator to adhere to ethical standards in research. First, some of these norms promote the aims of research, such as knowledge, truth, and avoidance of error. For example, prohibitions against fabricating, forging, or misrepresenting research data to promote the truth and avoid error. Second, since research often involves a great deal of cooperation and coordination among many different people in different disciplines and institutions, many of these ethical standards promote the values that are essential to collaborative work, such as trust, accountability, mutual respect, and fairness. For instance, one particular ethical norm, confidentiality, is designed to protect intellectual interests while encouraging collaboration among the participants. Third, ethical norms in research also help to build public support for research. People are more likely to fund research project if they can trust the quality and integrity of research (this particular example is relevant to the scenario being assessed.) Finally, many of the standards of research promote a variety of other important moral and social values, such as social responsibility, human rights, and compliance with the law So although all these codes, policies and principles are very important and useful but like any set of rules they do not cover every situation that arises in research, they are often conflicting and require considerable interpretation. It is therefore important for the researcher to learn how to interpret, assess and apply various research rules and how to make decisions about how to act in various circumstances. The vast majority of decision making in the conduct of research involves the straightforward application of ethical policies. Ethical issues that are encountered in applied social research are both subtle and complex, raising difficult moral dilemmas that, from the outside, appear unresolvable. With these dilemmas the researcher is required to strike a delicate balance between the scientific or social requirement of methodology and the human rights and values potentially threatened by the research. Privacy and confidentiality are two ethical issues that are crucial to social researchers who request individuals to share with them their thoughts attitudes and experiences. The ethical social researcher is one who is aware of ways in which privacy and confidentiality may be jeopardised and safeguarded and is knowledgeable about the effects of privacy and confidentiality on consent. The nature of privacy concerns has changed over time as social scientists have become more involved in identifying social problems and testing possible solutions through field research (Boruch Cecil, 1979) Organisational research focus is directed toward personnel relating issues, including the testing and appraisal of employees for personnel decisions. In conducting these investigations, researchers and consultants may seek to improve on organisations capacities to achieve various goals (e.g. profit for a business, its employees quality of work life or the impact of the organisation on communities in isolate rural areas. Evaluation research is a major type of applied research, typically undertaken by social scientists to determine if ongoing social programs are working as they should. Evaluations tend to focus on programs that are beneficial in nature, such as remedial education, health care and job training programs. The results of an evaluation study, in revealing whether a social program is accomplishing what was intended can have immediate impact on social policy and political decisions regarding the programs fate whether it should be continued or stopped, its budget and personnel increased or cut backs made. There are a number of vested interests in the design and implementation of evaluation studies and because their results are likely to affect peoples jobs, education and health. Like research conducted in organisations, evaluation research raises some unique ethical questions about whose interests are served an whose point of view should be represented during the research process (Kidder Judd, 1986) With this particular scenario there are two different situations where ethical issues will arise. Firstly, you begin to suspect that food is being stolen from the kitchen and the viability of the project may be at risk. From a researchers point of view suspicions would need to be backed up with hard evidence. If you were to say to you manager, you run the risk of them discharging you and not allowing you to carry out anymore research how could you possibly imagine that of any of their staff? Although on the other hand if your manager was to take you suspicions on board and further investigate the matter over a closely surveyed period of time, they may benefit and appreciate your integrity that you hold with the company. In a case like this it is often difficult for the evaluator to separate their research role from their role as a work experience placement student. You have been promised the confidentiality of the staff and if you were to say anything about the stolen food it could affect your research and you rapport with the staff. The staff may turn against you and refuse to cooperate after you telling the boss on one of their colleagues. Throughout the research you must remember what the objective is and if you remain silent with your suspicions, will your results in anyway end up being bias? This will reflect an untrue outcome and the company could face further scrutiny from the funding body. There is also the legality aspect for the researcher to consider and stealing is against the law, could you live with yourself if you thought that you were covering up for a criminal, no matter how small the offence was? In failing to voice your suspicions Kimmel, (1988) stated you legally could face prosecution as an accessory after the fact for failure to report a crime. If I were to be placed in this situation I personally would confront the manager of the company and explain my situation with regards to my research. I believe that stealing is wrong and should not take place no matter how big or small the offence is. Although I can understand why somebody may not say and not only put their research at rick but their social responsibility. The second scenario where the researcher will be confronted by ethical dilemmas is in carrying out the interviews with some of the senior citizens that are receiving these Meals on Wheels. To carry out interviews you will need the consent of the person involved, some elderly clients may not like the prospect of being intimated with questions. The elderly are of the vulnerable sector in our population and should be informed of why the interview is taking place and the effects that their answers could have on the survival and funding of the business while always remembering the objectivity of the research and expressing it in clarity to the senior citizens. The interview will involve asking how they feel about receiving their Meals on Wheels, how they approve of the service and how would they feel if this service was to be taken away from them? This could cause distress and emotional shock among the elderly, especially if they thought that their opinion meant the deciding factor of whe ther the company received funding to continue its business. Many of the elderly could largely depend on this service and there must be no deception in making them fully aware why the interviews are taken place. The senior citizens should be made aware that the researcher will be evaluating and publishing their results to the company and will have to give an open and honest account of what has been said in the interviews. The researcher is under the obligation from the code of ethics so as not to fabricate the data in anyway. The researcher, if a member of the local community, may feel tempted to fabricate the interview responses so as the company will receive their funding to finance this project as they realise how vital this scheme is for the elderly in this isolated rural area but as Kimmel noted personnel values may play a significant role in social research, therefore researchers must be careful enough to protect the integrity of their inquiries through careful data collection and analysis and accurate and objective reporting of their research findings. If I were the researcher in carrying out the interviews I would make the elderly entirely aware of the project and encourage them to see how they are beneficiaries of it. This in return will boost their confidence of the company and help portray a better interview for the research. After all if you were a senior citizen who lived in an isolated area and the only person you may see everyday is the delivery driver of Meals on Wheels, wouldnt you appreciate the service? Not only are they providing a food service but they also help to bring a warm and friendly atmosphere into the home. In conclusion ethical decision making is neither a perfectly rational nor entirely timeless enterprise, and even after a considered judgement about the issues involved in a given situation has been made, doubts about whether or not ones subsequent behaviour was ethical may remain. As we continue to proceed with social research in applied settings, we can expect a growing wealth of documentation on the conditions under which certain interventions are successful in reducing certain social problems and on what side effects might be anticipated as a result of their implementation. To proceed ethically it is important for social researchers to bear in mind that their first obligation is to those persons who cooperate with and participate in the research process, and that it is their interests that first must be considered during the preparatory stages of program development. References Kimmel, A (1988) Ethics and Values in Applied Social Research Sage Publications London

Scott Joplin and His Musical Legacy :: Entertainment Biographies Papers

Scott Joplin and His Musical Legacy "He just got his music out of the air," said one neighbor. One cannot hear the word "ragtime" without thinking of the "King of Ragtime," Scott Joplin. He is clearly one forerunner in the field of American music, particularly at the turn of the twentieth century. Not only was he a genius in the musical frame of mind, he also displayed strong talents in other areas. He had a kinesthetic gift, as seen in the movements he created for his dramatic productions. It was often said that if times were different and not so segregated, he could have been a great choreographer. He was also talented in the interpersonal field, as his music touched so many people throughout the years. Through his efforts ragtime is now a respected form of music in our history, although he did not live to see this fulfillment of his dreams. Background Joplin's father, Jiles, was only a small boy when he was purchased in South Carolina and taken to Texas. He had the privilege of being one of the few black slaves to be a house worker, which decreased his chances of being sold. Jiles was freed in his late teens. Picking the last name of his former owner's son-in-law, he traveled south. There he met Florence Givens, who was freeborn. They married by "jumping over the stick," the only form of marriage available to blacks at that time. He was eighteen; she was nineteen. The Joplins were not a close family. It is said that the men "had traveling in their blood." Scott, the second of five children, was born on November 24, 1868. When he was a preschooler, they moved to the wild frontier town of Texarkana, Texas. Both Jiles and Florence were musically inclined and talented. Jiles played the violin, while Florence played the banjo and sang. They encouraged musical interest in the children, and all five had talent. Scott stood out above the rest. At an early age, he could pick out songs on his mother's banjo, on which he was proficient by age seven. He had perfect pitch and could duplicate any chord he heard. He had the ability, which he retained until the end of his life, to remember tunes and fragments he heard years before. He incorporated them with his own elements into original compositions. His talent did not go unnoticed. Area music teachers were impressed and offered instruction.

Open Religion Exam Review

What problem does global free trade cause? Explain â€Å"common good. † – the 3 essential elements for common good. What is social justice? 7 themes of Catholic Social teaching. What each theme teaches Explain globalization How much of the total world income do countries like Canada receive? How much of the total world income do the poorest people in developing countries receive? How has globalization become a nightmare for poor countries? Explain how globalization could lead to justice.Who is Craig Eagleburger. What issues does he care about? Who has he helped? How has he helped them? â€Å"Inside Your Threads†. What are the issues raised. How are these situations unjust? What could be done to bring justice to these situations? Who is Ryan Hershel? What issue does he care about? Who has he helped? How has he helped? Why are relationships important? Define intimacy. Briefly explain the 5 levels of intimacy Describe the stages Of the family life cycle. What Stage is your family in?What are the types of families? Describe the moral decision making model What are values? Describe standards for judging values Define or explain sex, sexuality, sexual orientation, heterosexual orientation, nonsexual orientation, abstinence, celibacy, chastity What are SST Is – list ‘bacteria caused' SST Is – treatment – list ‘virus caused' Stir – treatment 2 reasons why the Catholic Church calls for abstinence from sexual intercourse outside marriage What is Natural Family Planning (NAP)?What does it mean to be Catholic in today's society? Movies we watched this semester Power of One Stolen Summer Dan in Real Life Junk Ryan's Well It Take a Child Inside Your Threads pay it Forward Explain how each movie connects to a theme or topic discussed in class this semester.

History before the Revolutionary Era Essay Example

History before the Revolutionary Era Essay Example History before the Revolutionary Era Essay History before the Revolutionary Era Essay John Locke, the philosopher, stated that all individuals have the right to Life, Liberty, and the pursuit of Property.Thomas Jefferson, former President, suggested that Happiness should replace Property in Lockes statement.Most of Americans depend on the property to achieve happiness.For instance, before the American Revolution, slavery was used as a form of property, congregations did not have the freedom to explore other churches or religions, and the government set regulations that were not in the best interest of the public.The conflict between self-interest and public interest is a key reason to why the American Revolution began.Although, those that were more concerned with what was in the best interest of the public, the Republicans, won the American Revolution, conflict still arose from undergoing Republican ideology or the change for the better. The American Revolution attempted to escape political chaos due to the Loyalist Exodus, which ended support for the restoration of monarchy or kingdom.In May 1776, Congress passed a resolution calling for the authority to be totally suppressed and all the powers of government exerted under the authority of the people.Republican institutions did absorb the energy and intellect of an entire generation.However, Congress decision of, Who should rule at home?, or who would control the new representative institutions of government, led a generation of rival camps between the state and the central government. During the 1790s Alexander Hamiltons, secretary of the Treasury under George Washington, system of public finance and the ideas of the French Revolution also divided Americans into warring camps which led to organized political parties.

KiD CuDi, a Genre-Defying Artist Research Paper Example

KiD CuDi, a Genre KiD CuDi, a Genre-Defying Artist Paper KiD CuDi, a Genre-Defying Artist Paper Ghost Scott Ramon Seguro Mescudi, known better as KID CuDi, is considered a genre-defying artist. KID CuDis music classifies as hip-hop and rock, which seem to be opposites, but he effortlessly combines the two as if they were meant to be. CuDi released his most recent album on April 16, 2013 titled Indicud. Mad Solar was one of the more emotional and personal songs CuDi featured in his latest breathtaking albums. The song has an eerie feeling to it, but nevertheless, CuDi exonerates his feelings and inner thoughts into it. KID CuDi does not hesitate to open up the song powerful, stating that he is secluded and he questions if we really know one another. CuDi goes further into the first verse by stating that he knows that he is different and that no one understands him, but he is okay with being alone. Life and the people around others ultimately do affect their life, whether they are good or bad company. CuDi has been through bad times with recently dropping from G. O. O. D Music, drug abuse and withdrawal, child custody battles over his daughter, and even betrayal from who he thought were his riends. Those difficult times that made him question his life and pushed him towards loneliness, resulted in CuDi being cold blooded. Through all the hard times, music was an outlet to him. CuDi has changed because of the trials he has faced, and he has lost fans because of this change. If the public sees him a certain way, then that is perfectly fine to him because in the end he is doing well in his career. Fuck em is an expression used to show that the publics comments are disregarded in his mind because it is his life, not theirs. The hook is where KID CuDi is reaching out to those people who think he is and telling them that their opinion does not affect himself as a person. CuDi has always been known for being fascinated with outer space; his references with space symbolize being high, his inner thoughts, the loneliness and darkness that comes along with his life. The term Mad solar refers to a transition that he is making in his life and music career. Reaching a new step, he is satisfied with the altercations he has made to his life. Tying into the word solar, his life is brighter and more positive. CuDi wants the world to see his Juristic change, though their opinion is not relative, he wants to prove people wrong. The doubts that everyone has thrown at him make CuDi a more diligent artist; saying he is crazy and has changed ultimately fuels his fire to become back superior. KID CuDi gets into the heart of the song with the second verse. Through out the song, CuDi explained what he has been through but people continue to call him crazy though ne is living his lite the way ne wants to. He continues to say that his heart has been swollen, its been healin slow because he is still recovering from a break up with his girlfriend, CuDi does not want to age with out someone being there with him. This also refers to the ongoing custody battles for his daughter; he does not want to alone live at home with out her. Looking back on his life, there were moments that he realized some of who he thought were his friends, Just so happened to be skeptics. CuDi reflects on his life and what goes on through his head, trying to reach eep down and see if he truly knows himself. There were many dishonest people in CuDis life that were never really there for him, but claimed to know him. Years went on, being deceived by backstabbers whom he thought were close to him. Those people made him question who he really is and misjudge his future because they blinded him. He goes to say that there is not any room for people who take space up in his life anymore, if you are not really there for him then do not attempt to make a place in his life.

Contemporary Issues Assignment 2 Essay Example | Topics and Well Written Essays - 2000 words

Contemporary Issues Assignment 2 - Essay Example This demographic appears as being unique because of societal stereotypes that with age comes ignorance as far as technology is concerned. Thus, the elderly are not expected by mainstream society to be frequent Internet users and vocal on sites such as social media platforms. This stereotyping has led to the loss of business opportunities by many corporates all over the globe (Aaker, 000, p.81). This can be extrapolated from the fact that silver surfers represent a market and workforce base that is more often than not unexploited almost in its entirety (Aras, 2009, p.55). Silver-Surfer demographic is relevant to any contemporary commercial organization primarily because of the timeline of operations of people in this group. A majority of people in this age demographic have retired from formal employment or are en route to do so in a few years. As a result, people in this age group do not have restrictions that are present in other age groups, the most common of which is time (Bratton, Jeffrey, 2000, p.201). People in this age group work on a more flexible timetable as opposed to their age groups where people are working multiple jobs at the same time (Bonhoeffer, 2001, p.91). This demographic group is therefore very significant in any contemporary commercial organization because of the flexibility of this group as far as time is concerned. Silver surfers present an operations base that is primarily unexploited. Society tends to shy away from the old in any formal setting. These emotions and reactions are fuelled by stereotypes that people in this age demographic are very dull as far as their social interaction is concerned (Schneider, 2004, p.50). The result is a very capable and highly experienced workforce that is greatly unexploited. Any contemporary commercial organization considering hiring silver surfers can use this as a public relations strategy to rid the world of societal

Urban Sociology Essay Example | Topics and Well Written Essays - 1000 words

Urban Sociology - Essay Example Urban Sociology After some time we have seen that the lock on the main door was broken & the door is open.As the problem becomes big & big it is very hard to solve the problem and also the control the reoccurrence of the problem. Due to lack of time we are not able to repair the lock & the door remain open. After some time we found the glasses fixed on windows are also broken and the floor of the house is full of waste material. Time to time the condition of the house became worst. The material inside the house was theft and every thing was broken within a short span of time. If the lock of the door was repaired in time then definitely there will not be such damage in the house. So the broken window theory clearly state that if we take action initially then we can prevent big damage and crime. For this State of New Jersey announced a "Safe and Clean Neighborhoods Program designed to improve the quality of community life in twenty-eight cities. According to this program, police officer should move in the city without vehicle means they need to move on foot to minimize crime. The objective is to secure the citizen. Citizens in the foot patrol areas had a more favorable opinion of the police than did those living elsewhere. And officers walking beats had higher morale, greater job satisfaction, and a more favorable attitude toward citizens in their neighborhoods than did officers assigned to patrol cars. Jacob found the relationship between the environmental factors and the people. Jacob found how physical & social urban factor affect the life of people. Jacob discovered how environmental factors cause prevention of crime. Jacob hypothesized that urban residential crime could be prevented by reducing conditions of anonymity and isolation in that area. Jacob thought that crime rate is increasing due to attitude of the people towards their neighbors. Even neighbors do not recognize each others. That's why they do not know whether the stranger entering into the society is a member o f society or not. Jocb stated that high levels of natural surveillance created a safe environment. According to Jacob one of our best protections against crime is to live in a community where neighbors watch out for each other and stand ready to call the police or to intervene directly where they spot a criminal. (c.) Explain Duneier's criticism of the broken windows theory as applied to the Greenwich Village vendors and panhandlers he studied. Greenwich vendors & panhandlers were first studied by Jane Jacobs in 1961, after that she wrote a book "The Death and Life of Great American Cities, which represented Greenwich Village sidewalk interaction as the ideal for what makes up a "great" American city. Duneier revisited the Jacobs principal by went back to the neighborhood. On the sidewalk, he studied the vendors who are not having houses, scavengers, and panhandlers. While side walking he found that the people are filled with illegality, personal defect, and shame and also a world of mutual support, struggles for respectability, ingenuity, and resilience. Duneier's main agenda was to understand the ways in which "moral" behavior and "decency" affects the crime. He also found that the sidewalk was quite different than it was when Jacobs described it, when "eyes and ears upon the street" were presumed to make sidewalk life safe and comfortable. His method was participant observation, and he worked as a magazine scavenger and street vendor on and off during

The 180 Day Plan Essay Example | Topics and Well Written Essays - 1000 words

The 180 Day Plan - Essay Example The overall focus for this phase is to teach students appropriate behavior for the classroom. For September, the focus is on instruction. During this month, students are being introduced to the expectations of their teacher and their school. The teacher's role during this month is to instruct students in appropriate classroom behavior. A management strategy that is essential during this month is to teach only the skills that students need to progress, such as how to transition or how to turn in work. A recommendation that the plan has for teachers is to organize the classroom to decrease the chances of disruptive behavior. For October, the focus is on reinforcing and strengthening skills taught during the previous month. Teacher's should continue to teach desired behavior, but they should spend more time helping students establish appropriate patterns for their behavior. The teacher's role during this month is to review rules with students and preteach expected behaviors that student s continue to struggle with. A management strategy for this month is to not only reinforce students who follow classroom rules, but to also reinforce them for other appropriate behaviors. ... A management strategy for this month is to upgrade instructional procedures and increase the amount of time for practicing daily skills, for students who are not consistently meeting the teacher's expectations. A recommendation that the plan has for teachers is to begin to increase the standard for acceptable performance. Instead of reinforcing students each time they follow a classroom rule, the teacher should reinforce students who comply with the rules in difficult circumstances or for longer periods of time. The retention phase takes place during the months of December, January and February. The overall focus for this month is to help students master behavioral skills and academic competencies so that they can become independent learners. For December, the focus is to help students gain mastery over material, but maintain appropriate school and classroom behavior. The teacher's role during this month is to teach and reinforce independent and self-reliant behavior in the students. A management strategy for this month is to reinforce students who are trying to perform independently. A recommendation that the plan has for teachers is to look for students who are showing appropriate, independent behavior and reinforce them heavily. January can be a difficult time for students and teachers. Students have been on winter break for weeks and some may forget expected behavior or they may not retain material that they learned during the previous year. For January, the focus is to reintroduce previously learned rules and routines while, at the same time, helping students to regain their mastery of the academic content they learned the previous

Annotated Bibliography Essay Example for Free

Annotated Bibliography Essay In order for NHS to satisfy its requirement to transmit large medical imaging files in a timely and secure manner, they must be able to subscribe to circuits of the appropriate bandwidth at each remote office to address the local needs. Unfortunately, the remoteness of some of these locations have resulted in the limitation of network connectivity options. Therefore, the cost-effective alternative to expensive, high-bandwidth internet circuits is to use a WAN optimization solution. A WAN optimization solution consists of a network appliance at each location that focuses on increasing network performance. It accomplishes this through the use of a combination of data compression, content and object-caching, data deduplication and protocol optimization. A WAN optimization appliance works in conjunction with the available bandwidth at a location. The host site would have an appliance that would build ‘acceleration tunnels’ to each of the appliances located at the remote sites. The appliances at the remote sites would be sized based upon the number of users and the available bandwidth at that location. This solution has a number of advantages. It is a very cost-effective approach. Higher bandwidth circuits in remote areas tend to be expensive. The purchase of network appliances are normally a capital expenditure that can be amortized over the life of the product. This timeframe is normally 3 to 5 years. On the other hand, the addition of larger circuits is an operational expenditure that incurs a higher recurring cost on a monthly basis. Secondly, these appliances are transparent to the end user. They do not require additional software on the users’ computers, or require any special setup on a per-user basis. NHS would very likely fall into the Early Adopters category in the Technological Acceptance Curve for this solution (Rogers, 2003). These individuals quickly buy into an idea when the possibility of real benefits have been established. They are primarily concerned with finding a strong match between their needs and the expected benefits (Moore, 1999). The use  of WAN optimization appliances would be an excellent fit for NHS and would be easily accepted by NHS management due to the ability to provide an optimal, technical and cost-effective resolution to the issue they are facing at the remote locations. This solution would allow them the means to meet their requirement to transmit large data files. References Rogers, Everett (2003). Diffusion of Innovations (5th Edition). New York, NY: Free Press Moore, Geoffrey (1999). Crossing the Chasm. United States: Harper Business Essentials

High Performance Liquid Chromatography Experiment

High Performance Liquid Chromatography Experiment INTRODUCTION Pharmaceutical Analysis may be defined as the application of analytical procedures used to determine the purity, safety and quality of drugs and chemicals. The term Pharmaceutical analysis is otherwise called quantitative pharmaceutical chemistry. Pharmaceutical analysis includes both qualitative and quantitative analysis of drugs and pharmaceutical substances starts from bulk drugs to the finished dosage forms. In the modern practice of medicine, the analytical methods are used in the analysis of chemical constituents found in human body whose altered concentrations during disease states serve as diagnostic aids and also used to analyze the medical agents and their metabolites found in biological system. Qualitative inorganic analysis seeks to establish the presence of given element or inorganic compound in a sample. Qualitative organic analysis seeks to establish the presence of a given functional group or organic compound in a sample. Quantitative Quantitative analysis seeks to establish the amount of a given element or compound in a sample. The term quality as applied to a drug product has been defined as the sum of all factors, which contribute directly or indirectly to the safety, effectiveness and reliability of the product. These properties are built into drug products through research and during process by procedures collectively referred to as Quality control. Quality control guarantees with in reasonable limits that a drug products Is free of impurities. Is physically and chemically stable Contains the amount of active ingredients as stated on the label and Provides optimal release of active ingredients when the product is administered. Most modern analytical chemistry is categorized by two different approaches such as analytical targets or analytical methods. INTRODUCTION FOR CHROMATOGRAPHY: High performance liquid chromatography is the process, which seperates mixture containing two or more components under high pressure. In this the stationary phase is packed in column one end of which is attached to a source of pressurized liquid mobile phase. High performance liquid chromatography is the fasted growing analytical technique for the analysis of drug. Its simplicity, high specificity and wide range of sensitivity makes its ideal for the analysis of many drugs in both dosage form and biologic fluids. HPLC is also known as High performance liquid chromatography. It is essential form column chromatography in which the stationary phase is consists of a small particles (3-5o µm) packing contained in a column with a small bore (2-5mm), one end of which is attached to source of pressurized liquid eluent(mobile phase). Different Types of Principles: According to the phases involved, HPLC can be classified into several types, which are as follows: Normal Phase Chromatography (NPC) Reverse Phase Chromatography (RPC) Liquid Solid Chromatography or adsorption HPLC Liquid Liquid Chromatography or Partition HPLC Ion exchange Chromatography or Ion exchange HPLC Size exclusion or gel permeation or steric exclusion HPLC 1. Normal Phase Chromatography (NPC): In normal phase chromatography, the stationary phase is more polar then the mobile phase, and the mobile phase is a mixture of organic solvents with out added water (e.g. isopropane with hexane) and the column packing is either an inorganic adsorbent (silica) are a polar bonded phase (cyanno, diol, amino) on a silica support. Sample retention in normal phase chromatography increases with the polarity of mobile phase decreases. They are eluted in the order of increasing polarities. 2. Reverse Phase Chromatography (RPC): In reverse-phase chromatography, the stationary phase is less polar than the mobile phase and the mobile phase is a mixture of organic and aqueous phase. Reverse-phase chromatography is typically more convenient and rugged than the other forms of liquid chromatography and is more likely to result in a satisfactory final separation. High performance RPC columns are efficient, stable and reproducible. In this, the solutes are eluted in the order of their decreasing polarities. These are prepared by treating the surface silanol group of site with an organic chloro silane reagent. INSTRUMENTATION: RECORDER SCHEMATIC DIAGRAM OF HPLC a. Pumps: Pumps are required to deliver a constant flow of mobile phase at pressures ranging from 1 550 bar pumps capable of pressure up to 6000 psi provide a wide range of flow rates of mobile phase, typically from 0.01-10ml min-1. Low flow rates (10-100à ¯Ã‚ Ã‚ ­l min-1) are used with micro bore columns, intermediate flow rates (0.5-2ml min-1) are used with conventional analytical HPLC columns, and fast flow rates are used for preparative or semi preparative columns and for slurry packing techniques. Mechanical pumps of the reciprocating piston type view a pulsating supply of mobile phase. A damping device is there fore required to smooth out the pulses so that excessive noise at high levels of sensitivity or low pressure does not detract from detection of small quantities of sample. This type of pump is mostly used. Dual piston reciprocating pumps produce an almost pulse free flow because the two pistons are carefully faced so that as one is filling the other is pumping. These pumps are more expensive than single piston pumps but are of benefit when using a flow sensitive detector such as ultraviolet or refractive index detector. b. Injection Systems: Injection ports are of two basic types, (A) those in which the sample with injected directly into the column and (B) those in which the sample is deposited before the column inlet and then swept by a valving action into the column by the mobile phase. c. Columns: HPLC columns are made of high quality stainless steel, polish internally to a mirror finish. Standard analytical columns are 4-5 mm internal diameter and 10-30 cm in length. Shorted columns (3-6 cm) containing a smaller particles size packing material (3 or 5 à ¯Ã‚ Ã‚ ­m) produce similar or better efficiencies, in terms of the number of theoretical plates (about 7000), that those of 20 cm columns containing 10 à ¯Ã‚ Ã‚ ­m irregular particles and are used an short analysis time and highest throughput of samples are required. Micro bore columns of 1-2 mm internal diameter and 10-25 cm in length have certain advantages of lower detection limits and lower consumption of solvent, the latter being important if expensive HPLC grade solvents are used. HPLC are also being carried out on the semi preparative scales by using columns of 7-10 mm or 20-40 mm internal diameter respectively. d. Detectors: The most widely used detectors for liquid chromatography are Detector Analytes Solvent Requirements Comments UV-Visible Any with chromophores UV-grade non UV absorbing solvents Has degree of selectivity and useful for many HPLC applications Fluorescence Fluorescent compounds UV-grade non UV absorbing solvents Highly selective and sensitive, often used to analyze derivitized compounds Refractive index Compounds with different RI than mobile phase Cannot run mobile phase gradients Limited sensitivity Conductivity Charged or polar compounds Mobile phase must be conducting Excellent for ion exchange compounds Electrochemical Readily oxidized or reduced compounds, specially biological samples Mobile phase must be conducting Very selective and sensitive Mass-Spectrometer Broad range compounds Must use volatile solvents or volatile buffers Highly sensitive. Many modes available. Needs trained person Theoretical principles of HPLC: a. Retention time: The time is required between the injection point and the peak maximum is called the retention time. It is denoted as the Rt. It is mainly useful for the qualitative analysis for the identification of compound. b. Capacity factor: It represents the molar ratio of the compound in the stationary phase and the mobile phase. It is independent of column length and mobile phase flow rate. It is denoted as the k. It should be kept 1-10. If k values are too low it is likely that the solutes may be adequately resolved and for high k values the analysis time is too long. It can be calculated by tr t0 k = - t0 tr = Retention time, t0 = Dead time. c. Tailing factor: Closer study of a chromatographic show that the Gaussian forms is usually not completely symmetrical. The graph spread out to a greater or lesser extent, forming a tail. It reduces the column plate number which intern influences the resolution. Tailing is mainly due to deteriorated column, overloading column, extra column-volumes, and incompatibility of sample with standard and/or mobile phase. Practically it can be calculated or determined at 10% of the total peak height. It must not be greater than 2.0 d. Resolution: The degree of separation of one component from another is described by the resolution. It is generally denoted by Rs. It is measured as the difference in retention time and the arithmetic mean of the two peak widths. tr2 tr1 Rs = 0.5(w1 + w2) tr2 = Retention time of first peak w1 = width of first peak tr1 = Retention time of second peak w2 = width of second peak e. Theoretical plates: It is important property of the column. It reflects its quality of separation and its ability to produce sharp, narrow peak and achieving good resolution of peak. N denotes it. 3500 X L (cm) Theoretical plates = - dp( µm) L = length of the column in cm, dp = diameter of the particle ( µm) It follows that if the exchange is fast and efficient, the theoretical plate will be small in size and there will be large number of plates in the column. f. Height equivalent to theoretical plate (HETP): Number of plates directly proportional to the column length (L) and inversely proportional to the diameter of the particles (dp). The value of H is a criterion for the quality of a column. Lower the HETP, higher is the efficiency of the column. Its value depends upon particle size, flow rate, viscosity of mobile phase. H = L/N L = Length of column, N = No. of theoretical plate HPLC method development: The wide variety of equipment, columns, eluent and operational parameters involved makes high performance liquid chromatography (HPLC) method development seem complex. The main objective of method development is to obtain a good separation with minimum time and effort. Based on the goal of separation, the method development is preceded. The steps involved are: Information on sample, define separation goals Need for special HPLC procedure, sample pretreatment, etc. Choose detector and detector settings Choose LC method, preliminary run; Estimate best separation conditions Optimize separation conditions Check for problems or requirement for special procedure Validation for release to routine laboratory The following must be considered when developing an HPLC method: Keep it simple Try the most common columns and stationary phases first Thoroughly investigate binary mobile phases before going on to ternary Think of the factors that are likely to be significant in achieving the desired resolution. Mobile phase composition, for example, is the most powerful way of optimizing selectivity whereas temperature has a minor effect and would only achieve small selectivity changes. pH will only significantly affect the retention of weak acids and bases. VALIDATION OF ANALYTICAL METHOD IN PHARMACEUTICAL ANALYSIS: Validation is documented evidence, which is completed to ensure that an analytical method is accurate, reproducible and robust over the specific range. The quality of the analytical data is a key factor in the success of a drug development program. The process of method development and validation has a direct impact on the quality of these data. Method validation: Method validation is the process to confirm that analytical procedure employed for a specific test is suitable for its intended use. Method needs to be validated or revalidated Before their introduction into routine use Whenever the conditions changes for which the method has been validated , e.g., instrument with different characteristics Whenever the method is changed, and the change is outside the original scope of the method. Depending on the use of the assay, different parameters will have to be measured during the assay validation. ICH and several regulatory bodies and Pharmacopoeia have published information on the validation of analytical procedures METHOD VALIDATION PARAMETERS: SPECIFICITY. ACCURACY. PRECISION. LINEARITY. ROBUSTNESS. SOLUTION STABILITY. The goal of the validation process is to challenge the method and determine the limit of allowed variability for the conditions needed to run the method. The following statistical parameters are to be determined to validate the developed method. Correlation coefficient(r): When the changes in one variable are associated or followed by changes in the other, it is called correlation. The numerical measure of correlation is called the coefficient of correlation and is defined by the relation. à ¯Ã‚ Ã¢â‚¬Å" (x x) (y -y) r = à ¢Ã‹â€ Ã… ¡ à ¯Ã‚ Ã¢â‚¬Å"(x -x) 2 à ¯Ã‚ Ã¢â‚¬Å"(y -y Regression equation: Regression equation= I + aC Y2 Y1 a = slope = X2 X1 I = Intercept = regression a C As a percentage of mean absorbance. 3. Standard Deviation: S = à ¢Ã‹â€ Ã… ¡ à ¯Ã‚ Ã¢â‚¬Å" (X- X!) 2/N 1 Where, X = observed values X! = Arithmetic mean = à ¯Ã‚ Ã¢â‚¬Å"X/N N = Number of deviations For practical interpretation it is more convenient to express S in terms of percent of the approximate average of the range of analysis is used in the calculation of S. This is called co-efficient of variation (C.V) or percent relative standard deviation (%RSD). C.V OR %RSD = 100* S/ X! Criteria for Validation of the Method CHARACTERISTICS ACCEPTABLE RANGE Specificity No Interference Accuracy Recovery (98-102%) Precision RSD Linearity Correlation Coefficient(r)>0.99 Range 80-120% Stability >24h or >12h DRUG PROFILE RIZATRIPTAN BENZOATE: Structure: Chemical name : N,N diethyl -5-(1H-1,2,4-triazol-1-1-ylmetyl)-1H Indole-3 Ethanamine monobenzoate Molecular Formula : C15H19N5.C6H5COOH Molecular weight : 391.47 Description: White crystalline powder Melting point: 178-1800C Solubility: Sparingly soluble in water and methanol Storage: Air tight container protect from light. Drug Category: Anti migraine drug THERAPEUTIC RATIONAL RIZATRIPTAN BENZOATE: CLINICAL PHARMACOLOGY: Mechanism of action: Rizatriptan binds with high affinity to human 5-HTIB and 5-HTID receptors leading to cranial blood vessel constriction. Pharmacokinetics: Absorption: Completely absorbed from GI tract, absolute bioavailability is 45% plasma peak concentration attained with in 1-1.5 hours (conventional tablet )or 1.6-2.5 hours (orally disintegrating tablet)after oral administration. Distribution: Crosses placenta and is distributed in to milk in animal, no studies in pregnant or nursing women. Metabolism: Metabolized principally via oxidative deamination by Mao-A to an inactive indole acetic acid metabolite Elimination: Excreted principally in urine(14% of dose as unchanged drug and 51 % a indole acetic acid metabolite Adverse effects: Dry mouth Dizziness Pain tightness/pressure in neck/throat/jaw. Nausea Chest pain Parasthesia Fatigue Dosage and administration: The dose range of Rizatriptan benzoate is 10-30mg orally once daily.Rizatriptan benzoate can be administer orally disintegrating tablet with out meals. LITERATURE REVIEW Sasmitha Kumar et al: has been developed UV spectroscopic method for estimation of Rizatriptan benzoate.The drug shows maximum absorption at 277 nm and 281 nm and obeys beer-lamberts law in the concentration of 0.5-20  µg/ml at 277 nm and 0.5-80  µg/ml at 281 nm respectively. The percentage recovery was found to be 97-100%. Madhukar et al; has been developed reverse phase high performance liquid chromatographic method for determination of Rizatriptan benzoate. The proposed method utilized column L1 inertsil ODS-3v, 250 nmx4.6 mm having particle size, 5 µm. The mobile phases were comprised of A, B of Acetonitrile and buffer pH 6.5 at UV detection 225 nm.The method shows recovery 96.64-97.71 Sachin jagthap et al; has been developed stability indicating reversed phase high performance liquid chromatographic method for the determination of Rizatriptan benzoate in bulk powder and in pharmaceutical formulations. The method utilizes c18 column having dimension 250mmx4.6 mm having particle size,5.0  µm using a mobile phase 0.01M sodium dihydrogen phosphate buffer: Methanol , at a flow rate 1ml/min at ambient temperature and detected at 225 nm.and the method was validated according to ICH guidelines Quizi zhang et al: has been developed, a high performance liquid chromatographic method for the determination of Rizatriptan benzoate in human plasma.using asingle step liqid liqid extraction with metyl tertiary butyl ether, the analytes separated usig amobile phase consisting of 0.05%v/v triehylamine in water adjusting ph 2.75 with 85% phosphoric acid and acetonitrile.fluroscence detection was performed at an excitation wavelength of 225 nm and an emission wavelength of 360 nm.The linearity for rizatriptan was within the concentration range of 0.5-50ng/ml. Rajendra Kumar et al: has been developed and validated stability a stability indicating high performance liquid chromatographic method for Rizatriptan benzoate.The force degradation studies were performed on bulk sample of Rizatriptan benzoate. The method utilizes a zorbax SB-CN column with dimension of 250 mmx4.6 mm, 5um column. The mobile phase consists of a mixture of aqueous potassium dihydrogen ortho phosphate (ph3.4), acetonitrile and methanol. Rauza bagh et al: has been developed a spectroscopic method for analysis of Rizatriptan benzoate in bulk and tablet dosage form. The Rizatriptan benzoate shows maximum absorbance at 225 nm. Beers law was obeyed in the concentration range of 1-10 µg/ml. AIM AND PLAN OF WORK The present aim is to develop a new simple and rapid analytical method to estimate the Rizatriptan benzoate The plan of the proposed work includes the following steps: To undertake solubility studies for analytical studies of Rosuvastatin calcium Develop initial chromatographic conditions. Setting up of initial chromatographic conditions for the assay of Rosuvastatin calcium Optimization of initial chromatographic conditions. Validation of the developed HPLC Analytical method according to ICH method validation parameters. EXPERIMENTAL NEW RP-HPLC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN TABLET DOSAGE FORM A simple reverse phase HPLC methods was developed for the determination of Rizatriptan benzoate in tablet dosage form. Zorbax Eclipse XBD C18 (250 cm ÃÆ'- 4.6 mm) column in isocratic mode with mobile phase Buffer ph 5.0: Methanol (80:20) was used and pH-3 adjusted with tri ethylamine. The flow rate was 1.0 ml/min and UV detection at 225nm. The retention time 3.0 min. The proposed method was also validated. EXPERIMENTAL 1. Instrumentation: Shimadzu LC-10A HPLC Vacuum pump Gelmon science Elico SL-164 double beam UV-Visible spectrophotometer Ultra sonicator 3.5L 100(pci) 2. Chemicals: Water HPLC grade Methanol HPLC grade (Merck) Potassium dihydrogen orthophosphate(AR Grade) Triethylamine (AR Grade) 5.1 OPTIMIZATION: 1. Selection of wavelength: After solubility study for the drug solvent was selected and appropriate concentration of Rizatriptan benzoate standards with solvent were prepared. The solution were then scanned by using doubl beam UV-Visible spectrophotometer the range between 200-400nm.The overlain spectra for the both drug were observed and maximum wavelength was finally selected. 2. Selection of mobile phase: To develop a prà ©cised and robust HPLC method for determination of Rizatriptan benzoate , its standard solution were injected in the HPLC system. After literature survey and solubility data different composition of mobile phase of different flow rates were employed in order to determine the best condition for effective separation of drugs. 3. Selection of column: Initially different C8 and C18 columns were tried for selected composition of mobile phase and quality of peaks were observed for the drugs. Finally the column was fixed upon the satisfactory results of various system suitability parameters such as column efficiency, retention time, tailing factor / peak asymmetry of the peaks. Other parameters such as flow rate, column temperature etc. were selected by varying its value up to certain levels and results were observed. The value at satisfactory results were obtained has been selected for the method. The final selection of chromatographic conditions as follows Optimized chromatographic conditions Preparation of Buffer ph 5.0: Dissove 2.76 gm of potassium dihydrogen orthophosphate in 1000ml of HPLC water plus 5.0 mlof Triethylamine. Mix and adjust PH 5.0 with orthophosporic acid. Filter with 0.45u nylon filter. Preparation of mobile phase: The mobile phase was prepared by mixing Buffer: Methanol (80:20). the solution was then filtered through 0.45ÃŽÂ ¼m membrane filter and sonicated. Preparation of standard stock solution: Standard solution of the pure drug was prepared by dissolving 73.0 mg of Rizatriptan benzoate in 100ml volumetric flask. The drugs were dissolved by using mobile phase as a diluent. Add about 50ml of diluent and sonicate to dissolve. Make up the volume with diluent. Mix well. Further dilute 5.0ml of the above solution to 250ml with diluent, mix well. Preparation of sample solution: Weight and transfer 10 intact tablet in into a100ml volumetric flask. Add about 50ml of diluent and sonicate for 15 min and make up the volume with diluent. Mix well, filter through 25 mm 0.45 u nylon , discard 4ml filtrate. Further dilute 5ml of the solution to 250 ml with diluent and mix well. CONCLUSION The evaluation of obtained values suggests that the proposed HPLC methods provide simple, precise, rapid and robust quantitative analytical method for determination of Rizatriptan benzoate in tablet dosage form. The mobile phase is simple to prepare and economical. After validating proposed method as per ICH guidelines and correlating obtained values with the standard values, satisfactory results were obtained. Hence, the method can be easily and conveniently adopted for routine estimation of Rizatriptan benzoate in tablet dosage form.