The 180 Day Plan Essay Example | Topics and Well Written Essays - 1000 words

The 180 Day Plan - Essay Example The overall focus for this phase is to teach students appropriate behavior for the classroom. For September, the focus is on instruction. During this month, students are being introduced to the expectations of their teacher and their school. The teacher's role during this month is to instruct students in appropriate classroom behavior. A management strategy that is essential during this month is to teach only the skills that students need to progress, such as how to transition or how to turn in work. A recommendation that the plan has for teachers is to organize the classroom to decrease the chances of disruptive behavior. For October, the focus is on reinforcing and strengthening skills taught during the previous month. Teacher's should continue to teach desired behavior, but they should spend more time helping students establish appropriate patterns for their behavior. The teacher's role during this month is to review rules with students and preteach expected behaviors that student s continue to struggle with. A management strategy for this month is to not only reinforce students who follow classroom rules, but to also reinforce them for other appropriate behaviors. ... A management strategy for this month is to upgrade instructional procedures and increase the amount of time for practicing daily skills, for students who are not consistently meeting the teacher's expectations. A recommendation that the plan has for teachers is to begin to increase the standard for acceptable performance. Instead of reinforcing students each time they follow a classroom rule, the teacher should reinforce students who comply with the rules in difficult circumstances or for longer periods of time. The retention phase takes place during the months of December, January and February. The overall focus for this month is to help students master behavioral skills and academic competencies so that they can become independent learners. For December, the focus is to help students gain mastery over material, but maintain appropriate school and classroom behavior. The teacher's role during this month is to teach and reinforce independent and self-reliant behavior in the students. A management strategy for this month is to reinforce students who are trying to perform independently. A recommendation that the plan has for teachers is to look for students who are showing appropriate, independent behavior and reinforce them heavily. January can be a difficult time for students and teachers. Students have been on winter break for weeks and some may forget expected behavior or they may not retain material that they learned during the previous year. For January, the focus is to reintroduce previously learned rules and routines while, at the same time, helping students to regain their mastery of the academic content they learned the previous

Annotated Bibliography Essay Example for Free

Annotated Bibliography Essay In order for NHS to satisfy its requirement to transmit large medical imaging files in a timely and secure manner, they must be able to subscribe to circuits of the appropriate bandwidth at each remote office to address the local needs. Unfortunately, the remoteness of some of these locations have resulted in the limitation of network connectivity options. Therefore, the cost-effective alternative to expensive, high-bandwidth internet circuits is to use a WAN optimization solution. A WAN optimization solution consists of a network appliance at each location that focuses on increasing network performance. It accomplishes this through the use of a combination of data compression, content and object-caching, data deduplication and protocol optimization. A WAN optimization appliance works in conjunction with the available bandwidth at a location. The host site would have an appliance that would build ‘acceleration tunnels’ to each of the appliances located at the remote sites. The appliances at the remote sites would be sized based upon the number of users and the available bandwidth at that location. This solution has a number of advantages. It is a very cost-effective approach. Higher bandwidth circuits in remote areas tend to be expensive. The purchase of network appliances are normally a capital expenditure that can be amortized over the life of the product. This timeframe is normally 3 to 5 years. On the other hand, the addition of larger circuits is an operational expenditure that incurs a higher recurring cost on a monthly basis. Secondly, these appliances are transparent to the end user. They do not require additional software on the users’ computers, or require any special setup on a per-user basis. NHS would very likely fall into the Early Adopters category in the Technological Acceptance Curve for this solution (Rogers, 2003). These individuals quickly buy into an idea when the possibility of real benefits have been established. They are primarily concerned with finding a strong match between their needs and the expected benefits (Moore, 1999). The use  of WAN optimization appliances would be an excellent fit for NHS and would be easily accepted by NHS management due to the ability to provide an optimal, technical and cost-effective resolution to the issue they are facing at the remote locations. This solution would allow them the means to meet their requirement to transmit large data files. References Rogers, Everett (2003). Diffusion of Innovations (5th Edition). New York, NY: Free Press Moore, Geoffrey (1999). Crossing the Chasm. United States: Harper Business Essentials

High Performance Liquid Chromatography Experiment

High Performance Liquid Chromatography Experiment INTRODUCTION Pharmaceutical Analysis may be defined as the application of analytical procedures used to determine the purity, safety and quality of drugs and chemicals. The term Pharmaceutical analysis is otherwise called quantitative pharmaceutical chemistry. Pharmaceutical analysis includes both qualitative and quantitative analysis of drugs and pharmaceutical substances starts from bulk drugs to the finished dosage forms. In the modern practice of medicine, the analytical methods are used in the analysis of chemical constituents found in human body whose altered concentrations during disease states serve as diagnostic aids and also used to analyze the medical agents and their metabolites found in biological system. Qualitative inorganic analysis seeks to establish the presence of given element or inorganic compound in a sample. Qualitative organic analysis seeks to establish the presence of a given functional group or organic compound in a sample. Quantitative Quantitative analysis seeks to establish the amount of a given element or compound in a sample. The term quality as applied to a drug product has been defined as the sum of all factors, which contribute directly or indirectly to the safety, effectiveness and reliability of the product. These properties are built into drug products through research and during process by procedures collectively referred to as Quality control. Quality control guarantees with in reasonable limits that a drug products Is free of impurities. Is physically and chemically stable Contains the amount of active ingredients as stated on the label and Provides optimal release of active ingredients when the product is administered. Most modern analytical chemistry is categorized by two different approaches such as analytical targets or analytical methods. INTRODUCTION FOR CHROMATOGRAPHY: High performance liquid chromatography is the process, which seperates mixture containing two or more components under high pressure. In this the stationary phase is packed in column one end of which is attached to a source of pressurized liquid mobile phase. High performance liquid chromatography is the fasted growing analytical technique for the analysis of drug. Its simplicity, high specificity and wide range of sensitivity makes its ideal for the analysis of many drugs in both dosage form and biologic fluids. HPLC is also known as High performance liquid chromatography. It is essential form column chromatography in which the stationary phase is consists of a small particles (3-5o µm) packing contained in a column with a small bore (2-5mm), one end of which is attached to source of pressurized liquid eluent(mobile phase). Different Types of Principles: According to the phases involved, HPLC can be classified into several types, which are as follows: Normal Phase Chromatography (NPC) Reverse Phase Chromatography (RPC) Liquid Solid Chromatography or adsorption HPLC Liquid Liquid Chromatography or Partition HPLC Ion exchange Chromatography or Ion exchange HPLC Size exclusion or gel permeation or steric exclusion HPLC 1. Normal Phase Chromatography (NPC): In normal phase chromatography, the stationary phase is more polar then the mobile phase, and the mobile phase is a mixture of organic solvents with out added water (e.g. isopropane with hexane) and the column packing is either an inorganic adsorbent (silica) are a polar bonded phase (cyanno, diol, amino) on a silica support. Sample retention in normal phase chromatography increases with the polarity of mobile phase decreases. They are eluted in the order of increasing polarities. 2. Reverse Phase Chromatography (RPC): In reverse-phase chromatography, the stationary phase is less polar than the mobile phase and the mobile phase is a mixture of organic and aqueous phase. Reverse-phase chromatography is typically more convenient and rugged than the other forms of liquid chromatography and is more likely to result in a satisfactory final separation. High performance RPC columns are efficient, stable and reproducible. In this, the solutes are eluted in the order of their decreasing polarities. These are prepared by treating the surface silanol group of site with an organic chloro silane reagent. INSTRUMENTATION: RECORDER SCHEMATIC DIAGRAM OF HPLC a. Pumps: Pumps are required to deliver a constant flow of mobile phase at pressures ranging from 1 550 bar pumps capable of pressure up to 6000 psi provide a wide range of flow rates of mobile phase, typically from 0.01-10ml min-1. Low flow rates (10-100à ¯Ã‚ Ã‚ ­l min-1) are used with micro bore columns, intermediate flow rates (0.5-2ml min-1) are used with conventional analytical HPLC columns, and fast flow rates are used for preparative or semi preparative columns and for slurry packing techniques. Mechanical pumps of the reciprocating piston type view a pulsating supply of mobile phase. A damping device is there fore required to smooth out the pulses so that excessive noise at high levels of sensitivity or low pressure does not detract from detection of small quantities of sample. This type of pump is mostly used. Dual piston reciprocating pumps produce an almost pulse free flow because the two pistons are carefully faced so that as one is filling the other is pumping. These pumps are more expensive than single piston pumps but are of benefit when using a flow sensitive detector such as ultraviolet or refractive index detector. b. Injection Systems: Injection ports are of two basic types, (A) those in which the sample with injected directly into the column and (B) those in which the sample is deposited before the column inlet and then swept by a valving action into the column by the mobile phase. c. Columns: HPLC columns are made of high quality stainless steel, polish internally to a mirror finish. Standard analytical columns are 4-5 mm internal diameter and 10-30 cm in length. Shorted columns (3-6 cm) containing a smaller particles size packing material (3 or 5 à ¯Ã‚ Ã‚ ­m) produce similar or better efficiencies, in terms of the number of theoretical plates (about 7000), that those of 20 cm columns containing 10 à ¯Ã‚ Ã‚ ­m irregular particles and are used an short analysis time and highest throughput of samples are required. Micro bore columns of 1-2 mm internal diameter and 10-25 cm in length have certain advantages of lower detection limits and lower consumption of solvent, the latter being important if expensive HPLC grade solvents are used. HPLC are also being carried out on the semi preparative scales by using columns of 7-10 mm or 20-40 mm internal diameter respectively. d. Detectors: The most widely used detectors for liquid chromatography are Detector Analytes Solvent Requirements Comments UV-Visible Any with chromophores UV-grade non UV absorbing solvents Has degree of selectivity and useful for many HPLC applications Fluorescence Fluorescent compounds UV-grade non UV absorbing solvents Highly selective and sensitive, often used to analyze derivitized compounds Refractive index Compounds with different RI than mobile phase Cannot run mobile phase gradients Limited sensitivity Conductivity Charged or polar compounds Mobile phase must be conducting Excellent for ion exchange compounds Electrochemical Readily oxidized or reduced compounds, specially biological samples Mobile phase must be conducting Very selective and sensitive Mass-Spectrometer Broad range compounds Must use volatile solvents or volatile buffers Highly sensitive. Many modes available. Needs trained person Theoretical principles of HPLC: a. Retention time: The time is required between the injection point and the peak maximum is called the retention time. It is denoted as the Rt. It is mainly useful for the qualitative analysis for the identification of compound. b. Capacity factor: It represents the molar ratio of the compound in the stationary phase and the mobile phase. It is independent of column length and mobile phase flow rate. It is denoted as the k. It should be kept 1-10. If k values are too low it is likely that the solutes may be adequately resolved and for high k values the analysis time is too long. It can be calculated by tr t0 k = - t0 tr = Retention time, t0 = Dead time. c. Tailing factor: Closer study of a chromatographic show that the Gaussian forms is usually not completely symmetrical. The graph spread out to a greater or lesser extent, forming a tail. It reduces the column plate number which intern influences the resolution. Tailing is mainly due to deteriorated column, overloading column, extra column-volumes, and incompatibility of sample with standard and/or mobile phase. Practically it can be calculated or determined at 10% of the total peak height. It must not be greater than 2.0 d. Resolution: The degree of separation of one component from another is described by the resolution. It is generally denoted by Rs. It is measured as the difference in retention time and the arithmetic mean of the two peak widths. tr2 tr1 Rs = 0.5(w1 + w2) tr2 = Retention time of first peak w1 = width of first peak tr1 = Retention time of second peak w2 = width of second peak e. Theoretical plates: It is important property of the column. It reflects its quality of separation and its ability to produce sharp, narrow peak and achieving good resolution of peak. N denotes it. 3500 X L (cm) Theoretical plates = - dp( µm) L = length of the column in cm, dp = diameter of the particle ( µm) It follows that if the exchange is fast and efficient, the theoretical plate will be small in size and there will be large number of plates in the column. f. Height equivalent to theoretical plate (HETP): Number of plates directly proportional to the column length (L) and inversely proportional to the diameter of the particles (dp). The value of H is a criterion for the quality of a column. Lower the HETP, higher is the efficiency of the column. Its value depends upon particle size, flow rate, viscosity of mobile phase. H = L/N L = Length of column, N = No. of theoretical plate HPLC method development: The wide variety of equipment, columns, eluent and operational parameters involved makes high performance liquid chromatography (HPLC) method development seem complex. The main objective of method development is to obtain a good separation with minimum time and effort. Based on the goal of separation, the method development is preceded. The steps involved are: Information on sample, define separation goals Need for special HPLC procedure, sample pretreatment, etc. Choose detector and detector settings Choose LC method, preliminary run; Estimate best separation conditions Optimize separation conditions Check for problems or requirement for special procedure Validation for release to routine laboratory The following must be considered when developing an HPLC method: Keep it simple Try the most common columns and stationary phases first Thoroughly investigate binary mobile phases before going on to ternary Think of the factors that are likely to be significant in achieving the desired resolution. Mobile phase composition, for example, is the most powerful way of optimizing selectivity whereas temperature has a minor effect and would only achieve small selectivity changes. pH will only significantly affect the retention of weak acids and bases. VALIDATION OF ANALYTICAL METHOD IN PHARMACEUTICAL ANALYSIS: Validation is documented evidence, which is completed to ensure that an analytical method is accurate, reproducible and robust over the specific range. The quality of the analytical data is a key factor in the success of a drug development program. The process of method development and validation has a direct impact on the quality of these data. Method validation: Method validation is the process to confirm that analytical procedure employed for a specific test is suitable for its intended use. Method needs to be validated or revalidated Before their introduction into routine use Whenever the conditions changes for which the method has been validated , e.g., instrument with different characteristics Whenever the method is changed, and the change is outside the original scope of the method. Depending on the use of the assay, different parameters will have to be measured during the assay validation. ICH and several regulatory bodies and Pharmacopoeia have published information on the validation of analytical procedures METHOD VALIDATION PARAMETERS: SPECIFICITY. ACCURACY. PRECISION. LINEARITY. ROBUSTNESS. SOLUTION STABILITY. The goal of the validation process is to challenge the method and determine the limit of allowed variability for the conditions needed to run the method. The following statistical parameters are to be determined to validate the developed method. Correlation coefficient(r): When the changes in one variable are associated or followed by changes in the other, it is called correlation. The numerical measure of correlation is called the coefficient of correlation and is defined by the relation. à ¯Ã‚ Ã¢â‚¬Å" (x x) (y -y) r = à ¢Ã‹â€ Ã… ¡ à ¯Ã‚ Ã¢â‚¬Å"(x -x) 2 à ¯Ã‚ Ã¢â‚¬Å"(y -y Regression equation: Regression equation= I + aC Y2 Y1 a = slope = X2 X1 I = Intercept = regression a C As a percentage of mean absorbance. 3. Standard Deviation: S = à ¢Ã‹â€ Ã… ¡ à ¯Ã‚ Ã¢â‚¬Å" (X- X!) 2/N 1 Where, X = observed values X! = Arithmetic mean = à ¯Ã‚ Ã¢â‚¬Å"X/N N = Number of deviations For practical interpretation it is more convenient to express S in terms of percent of the approximate average of the range of analysis is used in the calculation of S. This is called co-efficient of variation (C.V) or percent relative standard deviation (%RSD). C.V OR %RSD = 100* S/ X! Criteria for Validation of the Method CHARACTERISTICS ACCEPTABLE RANGE Specificity No Interference Accuracy Recovery (98-102%) Precision RSD Linearity Correlation Coefficient(r)>0.99 Range 80-120% Stability >24h or >12h DRUG PROFILE RIZATRIPTAN BENZOATE: Structure: Chemical name : N,N diethyl -5-(1H-1,2,4-triazol-1-1-ylmetyl)-1H Indole-3 Ethanamine monobenzoate Molecular Formula : C15H19N5.C6H5COOH Molecular weight : 391.47 Description: White crystalline powder Melting point: 178-1800C Solubility: Sparingly soluble in water and methanol Storage: Air tight container protect from light. Drug Category: Anti migraine drug THERAPEUTIC RATIONAL RIZATRIPTAN BENZOATE: CLINICAL PHARMACOLOGY: Mechanism of action: Rizatriptan binds with high affinity to human 5-HTIB and 5-HTID receptors leading to cranial blood vessel constriction. Pharmacokinetics: Absorption: Completely absorbed from GI tract, absolute bioavailability is 45% plasma peak concentration attained with in 1-1.5 hours (conventional tablet )or 1.6-2.5 hours (orally disintegrating tablet)after oral administration. Distribution: Crosses placenta and is distributed in to milk in animal, no studies in pregnant or nursing women. Metabolism: Metabolized principally via oxidative deamination by Mao-A to an inactive indole acetic acid metabolite Elimination: Excreted principally in urine(14% of dose as unchanged drug and 51 % a indole acetic acid metabolite Adverse effects: Dry mouth Dizziness Pain tightness/pressure in neck/throat/jaw. Nausea Chest pain Parasthesia Fatigue Dosage and administration: The dose range of Rizatriptan benzoate is 10-30mg orally once daily.Rizatriptan benzoate can be administer orally disintegrating tablet with out meals. LITERATURE REVIEW Sasmitha Kumar et al: has been developed UV spectroscopic method for estimation of Rizatriptan benzoate.The drug shows maximum absorption at 277 nm and 281 nm and obeys beer-lamberts law in the concentration of 0.5-20  µg/ml at 277 nm and 0.5-80  µg/ml at 281 nm respectively. The percentage recovery was found to be 97-100%. Madhukar et al; has been developed reverse phase high performance liquid chromatographic method for determination of Rizatriptan benzoate. The proposed method utilized column L1 inertsil ODS-3v, 250 nmx4.6 mm having particle size, 5 µm. The mobile phases were comprised of A, B of Acetonitrile and buffer pH 6.5 at UV detection 225 nm.The method shows recovery 96.64-97.71 Sachin jagthap et al; has been developed stability indicating reversed phase high performance liquid chromatographic method for the determination of Rizatriptan benzoate in bulk powder and in pharmaceutical formulations. The method utilizes c18 column having dimension 250mmx4.6 mm having particle size,5.0  µm using a mobile phase 0.01M sodium dihydrogen phosphate buffer: Methanol , at a flow rate 1ml/min at ambient temperature and detected at 225 nm.and the method was validated according to ICH guidelines Quizi zhang et al: has been developed, a high performance liquid chromatographic method for the determination of Rizatriptan benzoate in human plasma.using asingle step liqid liqid extraction with metyl tertiary butyl ether, the analytes separated usig amobile phase consisting of 0.05%v/v triehylamine in water adjusting ph 2.75 with 85% phosphoric acid and acetonitrile.fluroscence detection was performed at an excitation wavelength of 225 nm and an emission wavelength of 360 nm.The linearity for rizatriptan was within the concentration range of 0.5-50ng/ml. Rajendra Kumar et al: has been developed and validated stability a stability indicating high performance liquid chromatographic method for Rizatriptan benzoate.The force degradation studies were performed on bulk sample of Rizatriptan benzoate. The method utilizes a zorbax SB-CN column with dimension of 250 mmx4.6 mm, 5um column. The mobile phase consists of a mixture of aqueous potassium dihydrogen ortho phosphate (ph3.4), acetonitrile and methanol. Rauza bagh et al: has been developed a spectroscopic method for analysis of Rizatriptan benzoate in bulk and tablet dosage form. The Rizatriptan benzoate shows maximum absorbance at 225 nm. Beers law was obeyed in the concentration range of 1-10 µg/ml. AIM AND PLAN OF WORK The present aim is to develop a new simple and rapid analytical method to estimate the Rizatriptan benzoate The plan of the proposed work includes the following steps: To undertake solubility studies for analytical studies of Rosuvastatin calcium Develop initial chromatographic conditions. Setting up of initial chromatographic conditions for the assay of Rosuvastatin calcium Optimization of initial chromatographic conditions. Validation of the developed HPLC Analytical method according to ICH method validation parameters. EXPERIMENTAL NEW RP-HPLC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN TABLET DOSAGE FORM A simple reverse phase HPLC methods was developed for the determination of Rizatriptan benzoate in tablet dosage form. Zorbax Eclipse XBD C18 (250 cm ÃÆ'- 4.6 mm) column in isocratic mode with mobile phase Buffer ph 5.0: Methanol (80:20) was used and pH-3 adjusted with tri ethylamine. The flow rate was 1.0 ml/min and UV detection at 225nm. The retention time 3.0 min. The proposed method was also validated. EXPERIMENTAL 1. Instrumentation: Shimadzu LC-10A HPLC Vacuum pump Gelmon science Elico SL-164 double beam UV-Visible spectrophotometer Ultra sonicator 3.5L 100(pci) 2. Chemicals: Water HPLC grade Methanol HPLC grade (Merck) Potassium dihydrogen orthophosphate(AR Grade) Triethylamine (AR Grade) 5.1 OPTIMIZATION: 1. Selection of wavelength: After solubility study for the drug solvent was selected and appropriate concentration of Rizatriptan benzoate standards with solvent were prepared. The solution were then scanned by using doubl beam UV-Visible spectrophotometer the range between 200-400nm.The overlain spectra for the both drug were observed and maximum wavelength was finally selected. 2. Selection of mobile phase: To develop a prà ©cised and robust HPLC method for determination of Rizatriptan benzoate , its standard solution were injected in the HPLC system. After literature survey and solubility data different composition of mobile phase of different flow rates were employed in order to determine the best condition for effective separation of drugs. 3. Selection of column: Initially different C8 and C18 columns were tried for selected composition of mobile phase and quality of peaks were observed for the drugs. Finally the column was fixed upon the satisfactory results of various system suitability parameters such as column efficiency, retention time, tailing factor / peak asymmetry of the peaks. Other parameters such as flow rate, column temperature etc. were selected by varying its value up to certain levels and results were observed. The value at satisfactory results were obtained has been selected for the method. The final selection of chromatographic conditions as follows Optimized chromatographic conditions Preparation of Buffer ph 5.0: Dissove 2.76 gm of potassium dihydrogen orthophosphate in 1000ml of HPLC water plus 5.0 mlof Triethylamine. Mix and adjust PH 5.0 with orthophosporic acid. Filter with 0.45u nylon filter. Preparation of mobile phase: The mobile phase was prepared by mixing Buffer: Methanol (80:20). the solution was then filtered through 0.45ÃŽÂ ¼m membrane filter and sonicated. Preparation of standard stock solution: Standard solution of the pure drug was prepared by dissolving 73.0 mg of Rizatriptan benzoate in 100ml volumetric flask. The drugs were dissolved by using mobile phase as a diluent. Add about 50ml of diluent and sonicate to dissolve. Make up the volume with diluent. Mix well. Further dilute 5.0ml of the above solution to 250ml with diluent, mix well. Preparation of sample solution: Weight and transfer 10 intact tablet in into a100ml volumetric flask. Add about 50ml of diluent and sonicate for 15 min and make up the volume with diluent. Mix well, filter through 25 mm 0.45 u nylon , discard 4ml filtrate. Further dilute 5ml of the solution to 250 ml with diluent and mix well. CONCLUSION The evaluation of obtained values suggests that the proposed HPLC methods provide simple, precise, rapid and robust quantitative analytical method for determination of Rizatriptan benzoate in tablet dosage form. The mobile phase is simple to prepare and economical. After validating proposed method as per ICH guidelines and correlating obtained values with the standard values, satisfactory results were obtained. Hence, the method can be easily and conveniently adopted for routine estimation of Rizatriptan benzoate in tablet dosage form.

A Biography of Nelson Mandela :: Nelson Mandela Biography

A Biography of Nelson Mandela Nelson Rolihlahla Mandela is judged to be one of the greatest political leaders of modern times. Among his many accomplishments are the 1993 Nobel Peace Prize for his dedication to the fight against racial oppression in South Africa and establishing democracy there and becoming the president of South Africa in 1994 following their first multiracial elections. Nelson was born as the foster son of a Thembu chief in Umtata (now the province of Eastern Cape) and raised in a traditional tribal culture within the grips of apartheid, a powerful system of black oppression that existed in South Africa. After years as a poor student and law clerk in Johannesburg, he assumed an important role in the African National Congress (ANC), a civil rights group. He also helped form the ANC Youth League in the 1950's. He was accused of treason in 1956 but was acquitted in 1961. From 1960-1962 Mandela led the NAC's para military wing known as Umkhonto we Sizwe which translate to "Spear of the Nation." He was arrested in August of 1962, sentenced to five years in prison and while incarcerated was again convicted of sabotage and treason and was sentenced to life imprisonment in june, 1964 at the famous Rivonia Trial. During his twenty-seven years in prison, Nelson Mandela became a symbol of resistance to the white-dominated country of South Africa throughout the world. After complex negotiation, Mandela was finally released from prison by President F.W. deKlerk in February, 1990, after lifting the long ban on the ANC. Mandela's release from prison marked the beginning of the end of apartheid in South Africa when he once again became the head of the ANC. He began the process to from a new constitution in South Africa which would allow political power to the black majority. Finally in 1991 the South African government repealed the laws that had upheld apartheid. In May, 1994 Nelson Mandela became South Africa's first black president after the country's first multiracial elections were held. His goal was to provide for economic and social growth for the black majority that had been oppressed for so long by the system of apartheid.

Dutch and English Essay

The economic and political success of the Dutch and the English between 1570-1766 How the Dutch and English became successful was not only in trading but being merchants and bankers as well. When the other countries were busy fighting each other the Dutch were specializing in trading with them. Out of 20,000 trading vessels 16,000 of them were Dutch ships.† In the early 1400’s two thirds were based in Amsterdam.†The English and Dutch went to war over trading not only once but three times. The first was fought in 1652-54 the second in 1665-67 the third and final was in 1672-74 with the Dutch being the victor at Solo Bay in 1672. The most important thing to the Dutch was there trading, they even came up with something called the Maritime Insurance: with this people didn’t lose out on the profit. When the ships left port and out to sea nobody knew what would happen or if they were going to make it back, till the ship sailed into the harbor once aging. The Dutch even design a ship that was able to carry more goods and less people, it was a la rge bulk- carrying vessel called a flute or fly boat. The Dutch had trading stations and supply depots in many ports to name a few were: Norway, Ceylon, Java, Sumatra, Formosa,† which they took control of by 1641.† They were also the first to dominate the Baltic trade route between Spain, France, and England. The Dutch were able to pay a higher price for your goods and also give you credit, in doing this even if the crops were not ready yet the farmers still made sure they had something to sell to the Dutch. This meant a lower profit margin but the Dutch were able to profit since they had so much trade. There was even a market for Dutch paintings they were the first one to paint every day citizens doing every day things: form standing at the market, celebrations, or just having a good time. The  colors and demotions of the paintings is what made they more life like. Painting also showed how clean the homes and alleys were, of the farms the Dutch weren’t afraid to show everyone what they were like, took pride in showing people how they lived. Map making was another thing the Dutch did well they were able to lay it flat instead of in a cylinder shape. This way they were able to write on it redesign the different countries it was easier to measure how far you came or still needed to go. Education was available to anyone who wanted to learn woman and children, and not just to the rich but to everyone who wanted to learn. Pictures show that the schools were like an out of control daycare. Women were able to help run a business draw up contracts, women were just about equal to the men expect they couldn’t be on things like town counsels or like. Girard P.2 Women were still expected to get married and become a mother that was very important more then running a business. What was interesting was woman were able to go out by themselves and feel safe they didn’t need to worry about being abused, the other towns people looked after each other children they cared what happed to each other. The Dutch people seemed to always be talking about anything and anyone it didn’t matter where they were. In doing this people from other countries were surprised in this. The Dutch had an option on things form there own country two any other that might cross there mind. While other countries were fighting a religious war the Dutch were more laid back each religion had it place. At the some time there were many people moving to the Dutch Netherlands because they were able to study things like being a mathematician, even studying astrology. The Dutch showed the world what middle class family was and they didn’t need to starve or be poor; the farmers were able to sell their livestock or crops at the markets, they made a good living they didn’t dress in rags or dirty. In fact the Dutch were very clean, their homes were neat, even the back allies were keep clean and in order. The Dutch were very curious they wanted to know how the human body looked on the inside they even painted they doing an autopsy of the era. They were all about advance technology they used the ocean to power water wheels they dug canals to the wheels this powered the machinery, even  the wind was used for the windmills. The Dutch currency stayed the same, to help with the trading the first stock market was started in the Amsterdam town square. Not long after that the bank of Amsterdam was founded in 1694. Merchants were able to give credit and finance people. â€Å"Around 1700 the Dutch Netherland was ruled by the merchants mostly in Amsterdam it was the riches in province.† So while the rest of the world was taking from everyone and fighting over what religion was the right one the Dutch were trying to improve themselves trading was were the money was even if they had to spend money to make it they came away richer for it. They use the elements around them the ocean and the wind. There country men were there equals the country worked together. Things like money and finance was agreed on. The Dutch were traders, farmers, fishermen, merchants, bankers, even slave traders they did what they could to succeed in life while everyone else were fighting. Agriculture was a imporant econimc factor in England by the sixteenth century they had improved in better breading in their livestock, better dranges in the lower farmlands. People even came to England to learn how to farm. England imported other crops form different areas like rice from Asia.Trading was economicly favorable not as successful as the Dutch. Some of the English shipments were things like: â€Å"timber, flax, pitchwere the first of the Baltic trade†. England and the Dutch first went to was in 1652-54 the English were the victor. Some of England’s wealth came from the skilled craftsmen. They were invented and came up with new techniques.† Two centuries of gunnery had brought mining and metallurgy to a high pitch.† Girard P.3 In the year 1558 England got a new Queen named Elizabeth, she was the daughter of Henry the Eighth and Ann Boleyn. Before she became Queen her half sister imprisoned her in 1554 then final put her in exile in May 23 1554. When Elizabeth came to the throne due to fate she didn’t have the very men killed that tried to have her killed. Instead she bade them to place her in their hearts and have trust in her in other words. She talked to them as they were her equals, not just her royal subjects. On her coronation she asked nothing more of her subjects then to think of the good of England she stated that the common wealth of England comes first. Instead of fighting  amongst themselves she wanted them to stand together to fight their enemies. Spain and the Dutch were England’s greatest enemies. With the defeated of the Spanish in the Gulf of Mexico by John Hawkins in 1577 he was appointed treasurer of the navy. The English came up with a prototype of a ship in 1569 that was faster and easier to maneuver and had a better chance of hitting their target even in the turbulent whether. By 1588 the English had eighteen of them built. In 1776 saw another sea battle with Spain, during the next few years England would war with Spain three more times. Religion was a major political in England it seems from the start of the world: you had the crusades that were fought in the Holy Lands not only once but at lease three times. Everyone was trying to convert anyone they can to the true church. You had the Roman Catholic like John Knox an ordained priest. John Calvin who after braking from the Roman Catholic Church and becoming a Protestant around 1530, Calvinism and Lutheranism was the out come of that religion. Lutheranism was after a man named Martin Luther who was an Augustinian Monk. Because of him and his belief and thinking that we all didn’t need to follow one religion we today have many different faiths and we are able to choose what we are and what believe freely. Between the years of 1562-1598 there were at lease nine religion wars fought. Even under Elizabeth Catholics died because they were judged to be traders. In 1694 the bank of England was founded, the merchants were able to give credit and finance, there was a rise in the use of paper for currencies and instead of using bullions the cheque was invented. â€Å"Joint stock companies generated another form of negotiable security, their own share.† In the seventeenth century the coffee house were being taken over by the start of the London Stock exchange. Financer started to offer the public life insurance for the first time. The English became merchants and bankers when it was apparent that more money was to be made if they were more involved in the trading. The Economic gain of both the English and the Dutch were closely related, the trading and the banking. They soon realized that they would have to spend money to make it so that is how the Dutch came up with the stock market were everyone was able to have a share in. both countries were into slave trading, the Dutch started their West Indies company solely for the trading of slaves. This was an important economic for both countries. . Girard P.4 Another of England’s success was in the colonizing of the many countries and the discovery of even more. New York was a Dutch colony before England took it over. The other reason the English were successful because they didn’t wait for things to come to them they went out and took it. Whether it was the trading, farming, banking: both England and the Dutch kept trying to improve what they had in life. They still went out to make something of themselves discovering new countries and learning from there mistakes. One of the biggest successes the Dutch had been their trading routes. They didn’t just stop at a few they went on establishing many new shipping ports. Then they even designed ships that were able to carry larger bulk items, with less man power. They were able to give better bargains that made people wasn’t to trade with them. Back then it was important that you didn’t loose your product or that was the end of your money till the next season. The Dutch were so successful with their trading they had control over the Baltic trade routes, Spain, France, and England were just a few ports they traded with. The Dutch even had the environment working for them: they had advanced their technology where the ocean powered their water wheels, which powered the machinery. If the water wheels were inland they dug canals to where they needed the water. The wind was even utilized with the windmills that were spreading up across the country side. How they worked to maintain the shipping trade was everyone who could afford it bought stock in the company and that is how the first stock market was invented. The English on the other hand was a close second in the trading, one of the biggest commodes was the slave trade. The import trade was just an important this brought to England how to improve better breading with the livestock, the different crops like rice. then you had other shipments such as cotton and rubber just to name a few. Not only were the English traders but they became merchants industries were gaining a foot hold like the brewing establishments and the wool merchants. Mechanical and engineering skill clocks were done with mechanical interments. Brewing and textile establishments were also a growing business along side of the cloth and wool merchants that were spreading across the country side When Elizabeth became Queen she tried to improve the political stand point with England instead of fighting each  other she stated that the common wealth of England should come first. She talked to the people as if the were her equals and just her royal subjects. The economical success of both English and the Dutch was learning how to advance their trading what things worked and what didn’t. They applied and design different techniques the farm land and the crops were improving with every century and generation. Religion was always an issue in the political area you had your Roman catholic, or your Protestants. Then when Luther was making an issue of which god and belief was the true one two more faiths came into play and that was the Lutherans and Calvinists because of a man name John Calvin. The bible didn’t come into print till 1455 and that was the Gutenberg Bible. After that t5he people were able to read the words of God for themselves.

Concert Orchestra experience Essay

I went to the UNT Concert Orchestra on Wednesday, October 3rd, 2012. It was held in Winspear Hall at the Murchison Performing Arts Center at 8:00 pm. The Concert was led by Conductor Clay Couturiaux and featured soloist Christopher Deane, who played the Marimba. The first piece was Variations on a Theme of Tchaikovsky, Op. 35a (1894) by Anton Arensky (1861-1906). The piece was written in 1894, in tribute to Pyotr Il’yich Tchaikovsky (1840-1893). It was based on the theme from the poem â€Å"Legend†, written by Richard Henry Stoddard (1825-1903). This poem portrays the crucifixion of Christ. Arensky admired Tchaikovsky so much that he used the theme of â€Å"Legend† for a set of variations in the second movement of his Second String Quartet. This piece’s style is a themes and variations. Its instrumentation includes Cello solo, 2 Flutes, 2 Oboes, 2 Clarinets (A), 2 Bassoons + 2 Horns (F) + Violins I, Violins II, Violas, Cellos, and Double Basses. The second piece was Concerto for Marimba and Orchestra, Op. 34 (1957) by Robert Kurka (1921-1957). This piece introduced the marimba, which proved to the musical world that it could contend with instruments that had been used in orchestras and also provide a unique sound to the traditional orchestras played in regular concerts. This piece’s style is solo concerto. Its instrumentation includes the marimba and the orchestra. The third piece was Pictures at an Exhibition (1874) by Modest Mussorgsky (1839-1881). This piece was inspired by the paintings of the artist Viktor Hartmann (1834-1873). This piece’s style is an orchestral suite. Its instrumentation includes 3 Flutes (2nd and 3rd doubling Piccolos), 3 Oboes (3rd doubling Cor Anglais), 2 Clarinets in A and Bb, Bass Clarinet in A and Bb, Alto Saxophone, 2 Bassoons, Double Bassoon, 4 Horns in F, 3 Trumpet in C, 3 Trombones, Tuba, Timpani, Percussion (xylophone, triangle, rattle, whip, side drum, bass drum, cymbals, suspended cymbal), 2 Harps, Celesta, and Strings. I picked the pieces was Variations on a Theme of Tchaikovsky, Op. 35a (1894) by Anton Arensky and Concerto for Marimba and Orchestra, Op. 34 (1957) by Robert Kurka. Both of these pieces were distinctly different than one another. The piece by Arensky depicts a sense of deep sadness and despair as a whole. It starts out containing elements of intimacy and moves towards a slow moving harmony. The structure of the music matched the structure of the original poem. The variations of sounds expressed many shifting moods such as a dialogue between instruments. Mood changed quickly throughout the piece and showed different parts of the melody, from increments of joy, to sadness, to a deep sorrow. The rhythm seamlessly continued throughout the piece acting towards each of the different themes described in its construction. The piece by Kurka produced a new and different type of classical music that is unique to the orchestra. The use of the marimba stood out from the traditional orchestral instruments. The first movement begins with an alternation between the marimba and the orchestra. Its upbeat sound resonates in a catchy chiming sound whose rhythm is clear yet unexpected. It provides a playful side to a usually stern and focused orchestra. As the second movement begins, it as if the marimba is communicating to the orchestra itself. As if it is trying to fit in with these classic types of instruments through its unique dynamics and resounding tone. It seems to clash with its orchestral counterparts. By the third movement, it seems as if all the instruments reach an agreement on the legitimacy of the marimba through its colorful and exciting solo. Although both pieces are completely different than one another, they both exhibit emotion. Arensky exhibits cruel sounding music that discusses the importance of religion and a series of events that affects a wide variety of people. It evokes a sense of despair that expresses a deep sounding melody. Kurka exhibits a different type of music that discusses the marimba’s rise to becoming a part of classical orchestra. Its colorful timbre expresses a joyful and unique melody that pleases the human ear. Anton Arensky (12 July 1861 -25 February 1906), was a Russian composer of Romantic classical music, a pianist and a professor of music. Pyotr Tchaikovsky was the greatest influence on Arensky’s musical compositions. Indeed, Rimsky-Korsakov said, â€Å"In his youth Arensky did not escape some influence from me; later the influence came from Tchaikovsky. He will quickly be forgotten. † The perception that he lacked a distinctive personal style contributed to long-term neglect of his music, though in recent years a large number of his compositions have been recorded. Therefore, his values are seemingly non-existent because of the major influence of Tchaikovsky and absence of his own personal work. Throughout the performance I did perceive a strong sense of historical value and defines not who Arensky was, but his role model Tchaikovsky and how his music conveyed a strong sense of religious value. Kurka’s Concerto for Marimba and Orchestra was the first marimba work to enjoy both widespread public appeal and widespread recognition of having a high level of musical sophistication fit for the concert hall. It debuted during the modern style period. It provided important historical value by Kurka finally representing everything that early marimba composers set out to do in one piece: create a sophisticated and serious musical work that is both challenging to the performer and which has widespread public appeal. I perceived an ongoing struggle throughout the piece, but as the performance continued it conveyed the struggle the instrument had to do in order to become a prominent part of the classical orchestra. Citatation Keunning, G. (1999). Symphony of the canyons. Retrieved from http://lasr. cs. ucla. edu/geoff/prognotes/mussorgsky/pictures. html Strain, James. â€Å"Vida Chenoweth. † Percussive Notes 32. 6 (1994): 8-9. Print. Stevens, Leigh Howard. â€Å"An Interview with Vida Chenoweth. † Percussive Notes 15. 3 (2002): 22-25. PAS Online Archive . Weir, Martin. â€Å"Catching up with Vida Chenoweth. † Percussive Notes 32. 3 (1994): 53-55. Print.

A General Approach to the Air-Conditioning System essays

A General Approach to the Air-Conditioning System essays Human beings are born into a hostile environment, but the degree of hostility varies with the season of the year and with the geographical locality. For removing these effects of environment and changing outdoor conditions to the conditions we feel comfortable we use mechanical systems. Air conditioning system is the most developed system using for this purpose. Automotive air conditioning systems are used for controlling the conditions of air using in automotive. After investigations, negative effects of this system on the automotive are minimized and with using safety devices the usage area of the system are broaden. Now automotive air conditioning system are one of the most needed systems in automotive. Full air conditioning implies the automatic control of an atmospheric environment either for the comfort of human beings or animal or for the proper performance of some industrial or scientific process. The adjective full demands that the purity, movement, temperature and relative humidity of the air be controlled, within the limits imposed by the design specification. Air conditioning is always associated with refrigeration and it accounts for the high cost of air conditioning. The ability to counter sensible and latent heat gains is, then, the essential feature of an air conditioning system and, by common usage, the term air conditioning means that refrigeration is involved. Human beings are born into a hostile environment, but the degree of hostility varies with the season of the year and with the geographical locality. This suggests that the arguments for air conditioning might be based solely on climatic considerations, but although these may be valid in tropical and subtropical areas, they are not for temperate climates with industrialized social structures and rising standards of living. Air conditioning is necessary for the following reasons. Heat gains from human bodies, sunlight and el...